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    Gon7 GON7 subunit of KEOPS complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100233176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gon7provided by RGD
    Official Full Name
    GON7 subunit of KEOPS complexprovided by RGD
    Primary source
    RGD:2302582
    See related
    AllianceGenome:RGD:2302582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human GON7 (GON7 subunit of KEOPS complex). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 236.3), Testes (RPKM 172.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gon7 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127647389..127663276, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121882565..121898452, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126620597..126636484, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene uncharacterized LOC102548189 Neighboring gene uncharacterized LOC102548370 Neighboring gene modulator of apoptosis 1 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene BTB domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Wan LC, et al. Nucleic Acids Res, 2017 Jan 25. PMID 27903914, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EKC/KEOPS complex subunit GON7
    Names
    GON7, KEOPS complex subunit homolog
    uncharacterized protein C14orf142 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142941.1 → NP_001136413.1  EKC/KEOPS complex subunit GON7 isoform 1

      See identical proteins and their annotated locations for NP_001136413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      BF414510, BF561322, BI277056, BP482938, CB612989
      UniProtKB/TrEMBL
      A0A8I5ZXB8, A6JEL5
      Conserved Domains (1) summary
      pfam15387
      Location:3 → 95
      DUF4611; Domain of unknown function (DUF4611)

    2. NM_001142942.2 → NP_001136414.1  EKC/KEOPS complex subunit GON7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      CB612989, JAXUCZ010000006
      UniProtKB/TrEMBL
      D3Z9A4
      Conserved Domains (1) summary
      pfam15387
      Location:3 → 70
      DUF4611; Domain of unknown function (DUF4611)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      127647389..127663276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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