Wls Wnt ligand secretion mediator [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Wlsprovided by RGD
Full Name: Wnt ligand secretion mediatorprovided by RGD
Primary source: RGD:735139
See related: EnsemblRapid:ENSRNOG00000036816 AllianceGenome:RGD:735139
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr177
Summary: Enables mu-type opioid receptor binding activity. Involved in positive regulation of dendrite morphogenesis. Located in dendrite cytoplasm; dendrite membrane; and nucleus. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 704.1), Kidney (RPKM 642.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q45

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (251590653..251705991)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (248931885..249047248)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (266315036..266431220)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results link reduced expression of both the D2R and Wntless to the explicit motivation for heroin rather than to differences in total drug intake per se
Title: Low expression of D2R and Wntless correlates with high motivation for heroin.
The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
Title: Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
These findings suggest a previously unrecognized role for GPR177 in regulating cellular response to opioid agonist drugs, and could create new avenues of investigation regarding the pharmacotherapy of drug dependence.
Title: Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH140979 (e-PCR)
- UniSTS:222980

RH135449 (e-PCR)
- UniSTS:218726

RH131641 (e-PCR)
- UniSTS:214924

RH131683 (e-PCR)
- UniSTS:214966

RH127338 (e-PCR)
- UniSTS:210648

RH140822 (e-PCR)
- UniSTS:210648

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mu-type opioid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt protein secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior axis specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in cementum mineralization	ISO Inferred from Sequence Orthology more info
involved_in exocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt protein secretion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in organelle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein wntless homolog

Names: EVI; G protein-coupled receptor 177; evenness interrupted homolog; integral membrane protein GPR177; protein evenness interrupted homolog; wntless Wnt ligand secretion mediator

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085353.1 → NP_001078822.1 protein wntless homolog

See identical proteins and their annotated locations for NP_001078822.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC062391

UniProtKB/Swiss-Prot

Q6P689

UniProtKB/TrEMBL

A0A0G2K645

Conserved Domains (1) summary

pfam06664
Location:178 → 496

MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
NM_199408.3 → NP_955440.1 protein wntless homolog

See identical proteins and their annotated locations for NP_955440.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6P689

UniProtKB/TrEMBL

A0A0G2K645

Related

ENSRNOP00000052120.2, ENSRNOT00000055245.5

Conserved Domains (1) summary

pfam06664
Location:178 → 496

MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

251590653..251705991

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102736.2 → XP_038958664.1 protein wntless homolog isoform X2

UniProtKB/TrEMBL

A0A0G2K645

Conserved Domains (1) summary

pfam06664
Location:159 → 477

MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
XM_039102737.2 → XP_038958665.1 protein wntless homolog isoform X1

UniProtKB/TrEMBL

A0A0G2K645, A6HWU8

Conserved Domains (1) summary

pfam06664
Location:115 → 433

MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion