Asl argininosuccinate lyase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aslprovided by RGD
Official Full Name: argininosuccinate lyaseprovided by RGD
Primary source: RGD:619974
See related: EnsemblRapid:ENSRNOG00000000903 AllianceGenome:RGD:619974
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables argininosuccinate lyase activity. Involved in several processes, including argininosuccinate metabolic process; cellular response to cAMP; and cellular response to cytokine stimulus. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1197.6), Kidney (RPKM 605.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32295779..32313257)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26659664..26677136)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30160922..30178348)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enterocyte-derived ASL has a protective role in necrotizing enterocolitis.
Title: Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Local factors such as the NO produced by nNOS/ASS/ASL-positive neurons, could influence ASS/ASL-positive microglia cells avoiding or allowing the induction, in these cells, of iNOS.
Title: Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia.
24 h after reperfusion, number of nNOS-positive neurons and tpercentage of those co-expressing ASS and ASL were significantly increased in the animals with a longer survival. 144 h after ischemia there was almost complete restore of these neurons.
Title: Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

ASL (e-PCR)
- UniSTS:509969

AA818673 (e-PCR)
- UniSTS:249720

BF388305 (e-PCR)
- UniSTS:244919

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables argininosuccinate lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables argininosuccinate lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables argininosuccinate lyase activity	IEA Inferred from Electronic Annotation more info
enables argininosuccinate lyase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-arginine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-arginine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-arginine biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ammonia assimilation cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ammonia assimilation cycle	ISO Inferred from Sequence Orthology more info
involved_in arginine biosynthetic process via ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine biosynthetic process via ornithine	IEA Inferred from Electronic Annotation more info
involved_in arginine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in argininosuccinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ammonium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucagon stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in diaphragm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in urea cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: argininosuccinate lyase

Names: ASAL; arginosuccinase

NP_067588.2

EC 4.3.2.1

XP_006249307.1

EC 4.3.2.1

XP_038945643.1

EC 4.3.2.1

XP_063127677.1

EC 4.3.2.1

XP_063127678.1

EC 4.3.2.1

XP_063127679.1

EC 4.3.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.