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    Ccl27 C-C motif chemokine ligand 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362505, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ccl27provided by RGD
    Official Full Name
    C-C motif chemokine ligand 27provided by RGD
    Primary source
    RGD:1304660
    See related
    EnsemblRapid:ENSRNOG00000039530 AllianceGenome:RGD:1304660
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CCR3 chemokine receptor binding activity; CXCR chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Predicted to act upstream of or within regulation of actin cytoskeleton organization. Predicted to be active in extracellular space. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 40.3), Brain (RPKM 37.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccl27 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61737261..61744375, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56941402..56948511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58159066..58166182, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene interleukin 11 receptor subunit alpha 1 Neighboring gene uncharacterized LOC102547621 Neighboring gene similar to ribosomal protein S12 Neighboring gene C-C motif chemokine ligand 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR3 chemokine receptor binding  
    enables CXCR chemokine receptor binding  
    enables chemokine activity  
    enables chemokine activity  
    enables cytokine activity  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in biological_process  
    involved_in cell chemotaxis  
    involved_in cellular response to lipopolysaccharide  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in neutrophil chemotaxis  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    C-C motif chemokine 27
    Names
    chemokine (C-C motif) ligand 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108660.1 → NP_001102130.1  C-C motif chemokine 27

      See identical proteins and their annotated locations for NP_001102130.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Related
      ENSRNOP00000057330.2, ENSRNOT00000060594.4
      Conserved Domains (1) summary
      cl00134
      Location:76 → 128
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61737261..61744375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763627.4 → XP_008761849.1  C-C motif chemokine 27 isoform X2

      UniProtKB/TrEMBL
      A6IIX6
      Conserved Domains (1) summary
      cl00134
      Location:82 → 134
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...
    2. XM_006238074.5 → XP_006238136.1  C-C motif chemokine 27 isoform X1

      See identical proteins and their annotated locations for XP_006238136.1

      UniProtKB/TrEMBL
      A6IIX6
      Related
      ENSRNOP00000089578.2, ENSRNOT00000096308.2
      Conserved Domains (1) summary
      cl00134
      Location:97 → 149
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...
    3. XM_006238073.5 → XP_006238135.1  C-C motif chemokine 27 isoform X1

      See identical proteins and their annotated locations for XP_006238135.1

      UniProtKB/TrEMBL
      A6IIX6
      Conserved Domains (1) summary
      cl00134
      Location:97 → 149
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...
    4. XM_063287905.1 → XP_063143975.1  C-C motif chemokine 27 isoform X3

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
    5. XM_006238077.5 → XP_006238139.1  C-C motif chemokine 27 isoform X3

      See identical proteins and their annotated locations for XP_006238139.1

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Conserved Domains (1) summary
      cl00134
      Location:76 → 128
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...
    6. XM_063287904.1 → XP_063143974.1  C-C motif chemokine 27 isoform X3

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Related
      ENSRNOP00000101991.1, ENSRNOT00000124928.1
    7. XM_006238081.2 → XP_006238143.1  C-C motif chemokine 27 isoform X4

      See identical proteins and their annotated locations for XP_006238143.1

      UniProtKB/TrEMBL
      A6IIY3
      Conserved Domains (1) summary
      pfam00048
      Location:31 → 91
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like
    8. XM_063287907.1 → XP_063143977.1  C-C motif chemokine 27 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AC23
    9. XM_017593471.3 → XP_017448960.1  C-C motif chemokine 27 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AC23
    10. XM_039110225.2 → XP_038966153.1  C-C motif chemokine 27 isoform X6

      UniProtKB/TrEMBL
      A6IIY5
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