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    Crb3 crumbs cell polarity complex component 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crb3provided by RGD
    Official Full Name
    crumbs cell polarity complex component 3provided by RGD
    Primary source
    RGD:1565035
    See related
    EnsemblRapid:ENSRNOG00000070099 AllianceGenome:RGD:1565035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in positive regulation of cell junction assembly and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human CRB3 (crumbs cell polarity complex component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 92.1), Lung (RPKM 49.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crb3 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1985504..1990855)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1898531..1903860)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9982529..9986896, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene DENN domain containing 1C Neighboring gene tubulin, beta 4A class IVa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Gao Y, et al. Sci Rep, 2016 Jun 30. PMID 27358069, Free PMC Article
    2. Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Wong EW, et al. Proc Natl Acad Sci U S A, 2008 Jul 15. PMID 18621709, Free PMC Article
    3. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Stucke VM, et al. Mol Biol Cell, 2007 May. PMID 17332497, Free PMC Article
    4. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Rockich BE, et al. Proc Natl Acad Sci U S A, 2013 Nov 19. PMID 24191021, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRB3 is an actin microfilament regulator, playing a pivotal role in organizing actin filament bundles at the ectoplasmic specialization.
      Title: Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114421

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of subapical complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein crumbs homolog 3
    Names
    crumbs 3, cell polarity complex component
    crumbs family member 3
    crumbs homolog 3
    crumbs protein homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025661.2 → NP_001020832.1  protein crumbs homolog 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001020832.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      Q4V8I0
      Related
      ENSRNOP00000112488.1, ENSRNOT00000172872.1

    2. NM_001431889.1 → NP_001418818.1  protein crumbs homolog 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JY65, A6KQS4

    3. NM_001431892.1 → NP_001418821.1  protein crumbs homolog 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      Q4V8I0

    4. NM_001431894.2 → NP_001418823.1  protein crumbs homolog 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      Q4V8I0

    5. NM_001431896.1 → NP_001418825.1  protein crumbs homolog 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JY65, A6KQS4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1985504..1990855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244303.5 → XP_006244365.1  protein crumbs homolog 3 isoform X1

      See identical proteins and their annotated locations for XP_006244365.1

      UniProtKB/TrEMBL
      A0A0G2JY65, A6KQS4

    2. XM_017596317.3 → XP_017451806.1  protein crumbs homolog 3 isoform X1

      Related
      ENSRNOP00000078595.1, ENSRNOT00000119595.2

    RNA

    1. XR_010054571.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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