Azin1 antizyme inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Azin1provided by RGD
Official Full Name: antizyme inhibitor 1provided by RGD
Primary source: RGD:61934
See related: EnsemblRapid:ENSRNOG00000005333 AllianceGenome:RGD:61934
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oazi; Oazin
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Expression: Biased expression in Heart (RPKM 279.2), Lung (RPKM 261.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (71539711..71566515, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (69654773..69681578, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (77345646..77372398, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of AZIN1, and hence by inference, polyamines as novel regulators of the expression of the Arginine vasopressin gene.
Title: Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus.
findings suggested that antizyme inhibitor (AIn) contributed to a rapid increase in ODC at the G1 phase and also played a role in facilitating cells to complete mitosis during the cell cycle
Title: The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.
Wild-type antizyme inhibitor and the AZI(DeltaY) mutant are capable of direct interaction with cyclin D1 suggesting a potential mechanism for the antizyme-independent effects, and a novel function for antizyme inhibitor in cellular growth control.
Title: Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism.

Submit: New GeneRIF Correction

General gene information

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Markers

Azin1 (e-PCR), detects polymorphism
- UniSTS:531467

WI-9274 (e-PCR)
- UniSTS:44565

RH143277 (e-PCR)
- UniSTS:232524

RH140733 (e-PCR)
- UniSTS:222799

G19701 (e-PCR)
- UniSTS:54919

A001V45 (e-PCR)
- UniSTS:54920

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activator activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activator activity	ISO Inferred from Sequence Orthology more info
enables ornithine decarboxylase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of polyamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: antizyme inhibitor 1

Names: AZI; ornithine decarboxylase antizyme inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301702.1 → NP_001288631.1 antizyme inhibitor 1

See identical proteins and their annotated locations for NP_001288631.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal 5' non-coding exon, thus has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

F7FJZ4, Q6P7R3

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
NM_022585.2 → NP_072107.2 antizyme inhibitor 1

See identical proteins and their annotated locations for NP_072107.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

F7FJZ4, Q6P7R3

Related

ENSRNOP00000007999.3, ENSRNOT00000007999.7

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

71539711..71566515 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241569.3 → XP_006241631.1 antizyme inhibitor 1 isoform X2

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

A0A0G2JW87

Conserved Domains (2) summary

cd06831
Location:26 → 418

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 404

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
XM_063264178.1 → XP_063120248.1 antizyme inhibitor 1 isoform X2

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

A0A0G2JW87
XM_006241568.4 → XP_006241630.1 antizyme inhibitor 1 isoform X1

See identical proteins and their annotated locations for XP_006241630.1

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

F7FJZ4, Q6P7R3

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]
XM_017595068.2 → XP_017450557.1 antizyme inhibitor 1 isoform X1

UniProtKB/Swiss-Prot

Q63764

UniProtKB/TrEMBL

F7FJZ4, Q6P7R3

Conserved Domains (2) summary

cd06831
Location:26 → 419

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

COG0019
Location:40 → 405

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]