Errfi1 ERBB receptor feedback inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Errfi1provided by RGD
Official Full Name: ERBB receptor feedback inhibitor 1provided by RGD
Primary source: RGD:1307599
See related: EnsemblRapid:ENSRNOG00000058186 AllianceGenome:RGD:1307599
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Xxx; Ralt; gene 33; RGD1307599
Summary: Enables SH3 domain binding activity; kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and negative regulation of macromolecule metabolic process. Predicted to be located in cytosol and plasma membrane. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 791.9), Kidney (RPKM 289.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (166606841..166620124)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (161323981..161337289)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (167951564..167966011)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results showed that miR-126 could inhibit apoptosis and reactive oxygen species accumulation by targeting ERRFI1.
Title: Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1.
findings thus suggest that the stimulation of Errfi1 and Ifrd1 may be important for theca and granulosa cell differentiation and oocyte complexes expansion.
Title: Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon-related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary.
Chk1 plays a role in regulating RALT protein stability by facilitating the interaction between 14-3-3 and RALT.
Title: Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.
Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass.
Title: Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6.
RALT drives endocytosis and degradation of kinase-suppressed EGFR molecules
Title: A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.
The abundance of Errfi1 in the pineal gland exhibits a >10-fold increase at night, apparently under adrenergic cyclic AMP control.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
analysis of downregulation of Mig-6, Wnt-7b, and Wnt-9a during osteoarthritis; Wnt-7b is expressed also in osteoblast-like cells
Title: Expression of MIG-6, WNT-9A, and WNT-7B during osteoarthritis.
Gene 33 is a physiological feedback inhibitor of the EGFR, functioning to inhibit EGFR phosphorylation and all events induced by EGFR activation
Title: Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function.
MIG-6/RALT is a transcriptionally controlled inhibitor of mitogenic and transforming signals generated by the ErbB-2 oncogene. MIG-6/RALT forms a physical complex with activated ErbB-2 and co-localizes with ErbB-2 in living cells.
Title: Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain.
Loss of MIG-6/RALT mRNA and protein expression occurs in ERBB2-amplified breast cancer cell lines and enhances ERBB2 oncogenic signalling.
Title: Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelium development	ISO Inferred from Sequence Orthology more info
involved_in fat pad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat pad development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in limb joint morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within limb joint morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung epithelium development	IEA Inferred from Electronic Annotation more info
involved_in lung epithelium development	ISO Inferred from Sequence Orthology more info
involved_in lung epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung vasculature development	IEA Inferred from Electronic Annotation more info
involved_in lung vasculature development	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within progesterone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to 1-oleoyl-sn-glycerol 3-phosphate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to 1-oleoyl-sn-glycerol 3-phosphate	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to progesterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to steroid hormone	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in skin morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in skin morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in skin morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in uterine epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterine epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ERBB receptor feedback inhibitor 1

Names: gene 33 polypeptide; mig-6; mitogen-inducible gene 6 protein homolog; receptor-associated late transducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014071.1 → NP_001014093.1 ERBB receptor feedback inhibitor 1

See identical proteins and their annotated locations for NP_001014093.1

Status: PROVISIONAL

Source sequence(s)

BC083845

UniProtKB/Swiss-Prot

P05432

UniProtKB/TrEMBL

A0A8L2R6B1, A6IUE1

Related

ENSRNOP00000072811.3, ENSRNOT00000085315.3

Conserved Domains (2) summary

pfam09027
Location:4 → 67

GTPase_binding; GTPase binding

pfam11555
Location:313 → 365

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

166606841..166620124

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764262.4 → XP_008762484.1 ERBB receptor feedback inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8L2R6B1

Conserved Domains (2) summary

pfam09027
Location:4 → 66

GTPase_binding; GTPase binding

pfam11555
Location:237 → 289

Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6