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    Cxcr4 C-X-C motif chemokine receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60628, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cxcr4provided by RGD
    Official Full Name
    C-X-C motif chemokine receptor 4provided by RGD
    Primary source
    RGD:620465
    See related
    EnsemblRapid:ENSRNOG00000003866 AllianceGenome:RGD:620465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables small molecule binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Located in endosome. Used to study pulmonary hypertension and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 542.4), Lung (RPKM 351.9) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cxcr4 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (42630383..42634288, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (40077976..40081883, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (45314952..45318856, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120096242 Neighboring gene uncharacterized LOC134481488 Neighboring gene uncharacterized LOC102548838

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC108696

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C-C chemokine binding  
    enables C-C chemokine binding  
    enables C-C chemokine receptor activity  
    enables C-C chemokine receptor activity PubMed 
    enables C-X-C chemokine receptor activity PubMed 
    enables C-X-C motif chemokine 12 receptor activity  
    enables C-X-C motif chemokine 12 receptor activity  
    enables actin binding  
    enables myosin light chain binding  
    enables small molecule binding PubMed 
    enables ubiquitin binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 72
    Process Evidence Code Pubs
    acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway  
    involved_in CXCL12-activated CXCR4 signaling pathway  
    involved_in CXCL12-activated CXCR4 signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within T cell proliferation  
    acts_upstream_of_or_within ameboidal-type cell migration  
    acts_upstream_of_or_within aorta development  
    acts_upstream_of_or_within blood vessel endothelial cell migration  
    involved_in brain development  
    acts_upstream_of_or_within brain development  
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
    involved_in calcium-mediated signaling  
    acts_upstream_of_or_within calcium-mediated signaling  
    involved_in cardiac muscle contraction PubMed 
    involved_in cell chemotaxis  
    involved_in cell migration PubMed 
    acts_upstream_of_or_within cellular response to cytokine stimulus  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to cytokine stimulus  
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in detection of temperature stimulus involved in sensory perception of pain PubMed 
    involved_in endothelial cell differentiation PubMed 
    involved_in endothelial tube morphogenesis PubMed 
    involved_in epithelial cell development PubMed 
    involved_in generation of neurons  
    acts_upstream_of_or_within germ cell development  
    acts_upstream_of_or_within germ cell migration  
    acts_upstream_of_or_within hematopoietic stem cell migration  
    involved_in immune response  
    acts_upstream_of_or_within kidney development  
    acts_upstream_of_or_within motor neuron axon guidance  
    involved_in myelin maintenance  
    involved_in neural precursor cell proliferation  
    involved_in neurogenesis  
    involved_in neurogenesis PubMed 
    involved_in neuron migration PubMed 
    involved_in neuron migration PubMed 
    acts_upstream_of_or_within neuron migration  
    involved_in neuron recognition PubMed 
    involved_in osteoclast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within positive regulation of calcium ion import  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of chemotaxis PubMed 
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of dendrite extension PubMed 
    involved_in positive regulation of macrophage migration inhibitory factor signaling pathway  
    involved_in positive regulation of mesenchymal stem cell migration PubMed 
    involved_in positive regulation of neurogenesis PubMed 
    involved_in positive regulation of oligodendrocyte differentiation  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    involved_in positive regulation of vascular wound healing PubMed 
    involved_in positive regulation of vasculature development  
    involved_in regulation of calcium ion transport PubMed 
    involved_in regulation of cell adhesion  
    acts_upstream_of_or_within regulation of cell migration  
    involved_in regulation of chemotaxis PubMed 
    involved_in regulation of chemotaxis  
    acts_upstream_of_or_within regulation of neuron migration  
    involved_in regulation of programmed cell death PubMed 
    involved_in regulation of viral process PubMed 
    involved_in response to activity PubMed 
    involved_in response to hypoxia  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to tacrolimus PubMed 
    involved_in response to ultrasound PubMed 
    involved_in telencephalon cell migration PubMed 
    acts_upstream_of_or_within ventricular septum development  
    Items 1 - 25 of 72
    Component Evidence Code Pubs
    located_in cell leading edge  
    located_in cell surface  
    located_in cell-cell junction  
    located_in cytoplasmic vesicle  
    located_in early endosome  
    located_in early endosome  
    located_in endosome PubMed 
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in growth cone  
    located_in late endosome  
    located_in late endosome  
    located_in lysosome  
    located_in lysosome  
    located_in plasma membrane  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 4
    Names
    CXC chemokine receptor
    CXC-R4
    CXCR-4
    LESTR
    SDF-1 receptor
    chemokine (C-X-C motif) receptor 4
    chemokine receptor (LCR1)
    fusin
    leukocyte-derived seven transmembrane domain receptor
    stromal cell-derived factor 1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022205.3NP_071541.2  C-X-C chemokine receptor type 4

      See identical proteins and their annotated locations for NP_071541.2

      Status: VALIDATED

      Source sequence(s)
      BC089804, CO557829
      UniProtKB/Swiss-Prot
      F1LPN8, O08565, Q8VD47
      UniProtKB/TrEMBL
      A9CMB9
      Related
      ENSRNOP00000005143.5, ENSRNOT00000005143.8
      Conserved Domains (2) summary
      pfam12109
      Location:335
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      cd15179
      Location:36310
      7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      42630383..42634288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272571.1XP_063128641.1  C-X-C chemokine receptor type 4 isoform X1

      UniProtKB/TrEMBL
      A9CMB9
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