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    Epc1 enhancer of polycomb homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362678, updated on 9-Dec-2024

    Summary

    Official Symbol
    Epc1provided by RGD
    Official Full Name
    enhancer of polycomb homolog 1provided by RGD
    Primary source
    RGD:2324280
    See related
    EnsemblRapid:ENSRNOG00000014834 AllianceGenome:RGD:2324280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin-protein adaptor activity and enzyme-substrate adaptor activity. Involved in vascular associated smooth muscle cell differentiation. Predicted to be located in nuclear body; nuclear membrane; and nucleolus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Predicted to be active in site of double-strand break. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 163.9), Spleen (RPKM 127.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Epc1 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (59198513..59289535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54503358..54594444, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57303968..57394975, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 1, pseudogene 12 Neighboring gene marker of proliferation Ki-67, pseudogene 1 Neighboring gene ral guanine nucleotide dissociation stimulator-like Neighboring gene family with sequence similarity 95 member C Neighboring gene ral guanine nucleotide dissociation stimulator-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex  
    located_in nuclear body  
    located_in nuclear membrane  
    located_in nucleolus  
    located_in nucleoplasm  
    part_of nucleosome  
    located_in nucleus  
    part_of piccolo histone acetyltransferase complex  
    part_of piccolo histone acetyltransferase complex  
    is_active_in site of double-strand break  

    General protein information

    Preferred Names
    enhancer of polycomb homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309462.1NP_001296391.1  enhancer of polycomb homolog 1

      See identical proteins and their annotated locations for NP_001296391.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GEL3, A6K9H9, D4A6E4
      Related
      ENSRNOP00000019968.7, ENSRNOT00000019968.9
      Conserved Domains (2) summary
      pfam06752
      Location:531762
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:198
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      59198513..59289535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095281.2XP_038951209.1  enhancer of polycomb homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GEL3
      Conserved Domains (1) summary
      pfam06752
      Location:565766
      E_Pc_C; Enhancer of Polycomb C-terminus
    2. XM_003751704.4XP_003751752.1  enhancer of polycomb homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_003751752.1

      UniProtKB/TrEMBL
      A0A8I6G2P8, A0A8I6GEL3
      Related
      ENSRNOP00000078400.1, ENSRNOT00000117368.2
      Conserved Domains (2) summary
      pfam06752
      Location:581812
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7148
      EPL1; Enhancer of polycomb-like
    3. XM_063276006.1XP_063132076.1  enhancer of polycomb homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GEL3
    4. XM_039095280.2XP_038951208.1  enhancer of polycomb homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GEL3
      Conserved Domains (2) summary
      pfam06752
      Location:615816
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7148
      EPL1; Enhancer of polycomb-like

    RNA

    1. XR_005495222.2 RNA Sequence

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