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    Mpp7 MAGUK p55 scaffold protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpp7provided by RGD
    Official Full Name
    MAGUK p55 scaffold protein 7provided by RGD
    Primary source
    RGD:1305675
    See related
    EnsemblRapid:ENSRNOG00000018760 AllianceGenome:RGD:1305675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be involved in bicellular tight junction assembly; positive regulation of protein-containing complex assembly; and protein localization to adherens junction. Predicted to be located in adherens junction; bicellular tight junction; and nucleoplasm. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 100.2), Heart (RPKM 80.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpp7 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (60135096..60401814, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (55439939..55706810, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (60057077..60250303)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene proteasome activator subunit 1 like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134482777 Neighboring gene small Cajal body-specific RNA 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for tandem L27 domain-mediated polymerization. Yang X, et al. FASEB J, 2010 Dec. PMID 20702775
    2. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Stucke VM, et al. Mol Biol Cell, 2007 May. PMID 17332497, Free PMC Article
    3. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. Bohl J, et al. J Biol Chem, 2007 Mar 30. PMID 17237226
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MPP7-DLG1-LIN7 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MPP7-DLG1-LIN7 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 7
    Names
    membrane palmitoylated protein 7
    membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100575.1 → NP_001094045.1  MAGUK p55 subfamily member 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q5U2Y3
      UniProtKB/TrEMBL
      A0A8I6ASL7, A6KPM5
      Related
      ENSRNOP00000025458.7, ENSRNOT00000025458.9
      Conserved Domains (4) summary
      smart00569
      Location:16 → 68
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12033
      Location:232 → 292
      SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
      smart00072
      Location:384 → 563
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      60135096..60401814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095743.2 → XP_038951671.1  MAGUK p55 subfamily member 7 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Y3
      UniProtKB/TrEMBL
      A0A8I6ASL7, A6KPM5
      Conserved Domains (4) summary
      smart00569
      Location:16 → 68
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12033
      Location:232 → 292
      SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
      smart00072
      Location:384 → 563
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_039095742.2 → XP_038951670.1  MAGUK p55 subfamily member 7 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Y3
      UniProtKB/TrEMBL
      A0A8I6ASL7, A6KPM5
      Conserved Domains (4) summary
      smart00569
      Location:16 → 68
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12033
      Location:232 → 292
      SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
      smart00072
      Location:384 → 563
      GuKc; Guanylate kinase homologues
      cd00992
      Location:137 → 217
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. XM_063276474.1 → XP_063132544.1  MAGUK p55 subfamily member 7 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2Y3
      UniProtKB/TrEMBL
      A0A8I6ASL7, A6KPM5

    4. XM_063276475.1 → XP_063132545.1  MAGUK p55 subfamily member 7 isoform X2

      UniProtKB/TrEMBL
      A6KPM6

    5. XM_063276477.1 → XP_063132547.1  MAGUK p55 subfamily member 7 isoform X3

      UniProtKB/TrEMBL
      A6KPM6

    6. XM_063276476.1 → XP_063132546.1  MAGUK p55 subfamily member 7 isoform X3

      UniProtKB/TrEMBL
      A6KPM6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2Y3.2 GenPept UniProtKB/Swiss-Prot:Q5U2Y3

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