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    Nop2 NOP2 nucleolar protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nop2provided by RGD
    Official Full Name
    NOP2 nucleolar proteinprovided by RGD
    Primary source
    RGD:1304616
    See related
    EnsemblRapid:ENSRNOG00000018453 AllianceGenome:RGD:1304616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nol1
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosome biogenesis. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.6), Thymus (RPKM 45.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nop2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159618894..159630697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157932731..157944462)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157646759..157658502)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene uncharacterized LOC120102389 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene intermediate filament family orphan 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. Valdez BC, et al. Cancer Res, 1992 Oct 15. PMID 1394192
    2. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Sloan KE, et al. Cell Rep, 2013 Oct 17. PMID 24120868, Free PMC Article
    3. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Sigal A, et al. Nat Methods, 2006 Jul. PMID 16791210
    4. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
    Names
    NOP2 nucleolar protein homolog
    nucleolar protein 1
    putative ribosomal RNA methyltransferase NOP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191785.1 → NP_001178714.1  probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D4ACW1
      Related
      ENSRNOP00000024938.6, ENSRNOT00000024938.9
      Conserved Domains (2) summary
      TIGR00446
      Location:292 → 566
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      PRK10905
      Location:573 → 761
      PRK10905; cell division protein DamX; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159618894..159630697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286195.1 → XP_063142265.1  probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform X1

      UniProtKB/TrEMBL
      D4ACW1
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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