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    Cabp4 calcium binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365394, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cabp4provided by RGD
    Official Full Name
    calcium binding protein 4provided by RGD
    Primary source
    RGD:1306083
    See related
    EnsemblRapid:ENSRNOG00000022044 AllianceGenome:RGD:1306083
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in visual perception. Predicted to act upstream of or within neuron differentiation and phototransduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CABP4 (calcium binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 71.2), Thymus (RPKM 14.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cabp4 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210857223..210872431, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201428671..201442950, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219383452..219388009, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene transmembrane protein 134 Neighboring gene G protein-coupled receptor 152 Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene coronin 1B Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. Zeitz C, et al. Am J Hum Genet, 2006 Oct. PMID 16960802, Free PMC Article
    2. Characterization of C-terminal Splice Variants of Cav1.4 Ca2+ Channels in Human Retina. Haeseleer F, et al. J Biol Chem, 2016 Jul 22. PMID 27226626, Free PMC Article
    3. A critical role of CaBP4 in the cone synapse. Maeda T, et al. Invest Ophthalmol Vis Sci, 2005 Nov. PMID 16249514, Free PMC Article
    4. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Haeseleer F, et al. Nat Neurosci, 2004 Oct. PMID 15452577, Free PMC Article
    5. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, et al. Cold Spring Harb Perspect Biol, 2010 Aug. PMID 20668007, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within photoreceptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phototransduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinal bipolar neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retinal cone cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108926.1 → NP_001102396.1  calcium-binding protein 4

      See identical proteins and their annotated locations for NP_001102396.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HYU1, D3ZY59
      Related
      ENSRNOP00000001550.3, ENSRNOT00000001550.5
      Conserved Domains (1) summary
      PTZ00184
      Location:133 → 268
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210857223..210872431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269824.1 → XP_063125894.1  calcium-binding protein 4 isoform X3

    2. XM_039085454.2 → XP_038941382.1  calcium-binding protein 4 isoform X2

      Conserved Domains (1) summary
      PTZ00184
      Location:47 → 176
      PTZ00184; calmodulin; Provisional

    3. XM_039085440.2 → XP_038941368.1  calcium-binding protein 4 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:133 → 262
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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