Gpc6 glypican 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpc6provided by RGD
Official Full Name: glypican 6provided by RGD
Primary source: RGD:1593308
See related: EnsemblRapid:ENSRNOG00000062503 AllianceGenome:RGD:1593308
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in omodysplasia 1. Orthologous to human GPC6 (glypican 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 92.3), Kidney (RPKM 56.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (100437415..101435038)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (94030218..95027883)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (102164091..103174721)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF399195 (e-PCR)
- UniSTS:247554

RH135097 (e-PCR)
- UniSTS:218374

D10Chm22 (e-PCR)
- UniSTS:518152

GPC6 (e-PCR)
- UniSTS:505365

BE118647 (e-PCR)
- UniSTS:248861

RH128206 (e-PCR)
- UniSTS:211514

RH141325 (e-PCR)
- UniSTS:223321

D15Got90 (e-PCR)
- UniSTS:115551

Gpc6 (e-PCR), detects polymorphism
- UniSTS:466043

D15Mgh5 (e-PCR), detects polymorphism
- UniSTS:119421

D15Rat24 (e-PCR)
- UniSTS:119459

RH144677 (e-PCR)
- UniSTS:233922

D15RAT104 (e-PCR)
- UniSTS:121037

RH133768 (e-PCR)
- UniSTS:217051

d15rat51 (e-PCR)
- UniSTS:121075

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glypican-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.