Pemt phosphatidylethanolamine N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pemtprovided by RGD
Official Full Name: phosphatidylethanolamine N-methyltransferaseprovided by RGD
Primary source: RGD:3297
See related: EnsemblRapid:ENSRNOG00000054423 AllianceGenome:RGD:3297
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PLMT; Pempt; PHOMETH
Summary: Enables phosphatidylethanolamine N-methyltransferase activity and phosphatidylethanolamine binding activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; positive regulation of lipoprotein metabolic process; and response to ethanol. Located in brush border membrane and sarcolemma. Biomarker of metabolic dysfunction and alcohol associated liver disease. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1309.8) and Testes (RPKM 43.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (45275434..45349651, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44775910..44849990, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (46339821..46404640, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma homocysteine is regulated by phospholipid methylation, and is therefore lowered in enzyme-deficient rats.
Title: Plasma homocysteine is regulated by phospholipid methylation.
The hepatic activity of PEMT increased 50% in diabetic rats, whereas administration of retinoic acid was without effect.
Title: Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats.
The induction of programmed cell death and suppression of cell proliferation by fasting were associated with enhanced PEMT expression and activity, and with a decrease in CTP:phosphocholine cytidylyltransferase expression.
Title: Inactivation of PEMT2 in hepatocytes initiated by DENA in fasted/refed rats.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143802 (e-PCR)
- UniSTS:233048

Pemt (e-PCR), detects polymorphism
- UniSTS:546930

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosylmethionine-dependent methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidyl-N-methylethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylmethionine metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sphingomyelin biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylethanolamine N-methyltransferase

Names: PE N-methyltransferase; PEAMT; phospholipid methyltransferase

NP_037135.1

EC 2.1.1.17

EC 2.1.1.71

XP_038941214.1

EC 2.1.1.17

EC 2.1.1.71

XP_063124541.1

EC 2.1.1.17

EC 2.1.1.71

XP_063124542.1

EC 2.1.1.17

EC 2.1.1.71

XP_063124543.1

EC 2.1.1.17

EC 2.1.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013003.2 → NP_037135.1 phosphatidylethanolamine N-methyltransferase

See identical proteins and their annotated locations for NP_037135.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q08388, Q5BK89

UniProtKB/TrEMBL

A6HF23

Related

ENSRNOP00000100443.1, ENSRNOT00000163705.1

Conserved Domains (1) summary

pfam04191
Location:102 → 191

PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

45275434..45349651 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085286.2 → XP_038941214.1 phosphatidylethanolamine N-methyltransferase isoform X1

UniProtKB/TrEMBL

A0A8I6AJS4, A0A8L2RBC3

Related

ENSRNOP00000074801.2, ENSRNOT00000083698.3

Conserved Domains (1) summary

pfam04191
Location:138 → 227

PEMT; Phospholipid methyltransferase
XM_063268471.1 → XP_063124541.1 phosphatidylethanolamine N-methyltransferase isoform X2

UniProtKB/TrEMBL

A0A8I6GAY9

Related

ENSRNOP00000084752.1, ENSRNOT00000112526.2
XM_063268472.1 → XP_063124542.1 phosphatidylethanolamine N-methyltransferase isoform X3
XM_063268473.1 → XP_063124543.1 phosphatidylethanolamine N-methyltransferase isoform X4