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    Clk3 CDC-like kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171305, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Clk3provided by RGD
    Official Full Name
    CDC-like kinase 3provided by RGD
    Primary source
    RGD:621259
    See related
    EnsemblRapid:ENSRNOG00000030126 AllianceGenome:RGD:621259
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase activity. Predicted to be involved in protein phosphorylation and regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be located in intermediate filament cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CLK3 (CDC like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.0), Spleen (RPKM 107.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clk3 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (67048121..67063192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (58152155..58167196, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62528135..62543550, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1 Neighboring gene U6 spliceosomal RNA Neighboring gene enhancer of mRNA decapping 3 Neighboring gene single stranded DNA binding protein 1, pseudogene 4 Neighboring gene AT-rich interaction domain 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis. Becker W, et al. Biochim Biophys Acta, 1996 Jun 5. PMID 8679717
    2. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway. Ma X, et al. In Vitro Cell Dev Biol Anim, 2024 Apr. PMID 38438604
    3. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan PI, et al. Exp Cell Res, 1998 Jun 15. PMID 9637771
    4. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
      Title: CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK3
    NP_599167.2
    XP_006243208.1
    XP_038936675.1
    XP_063120894.1
    XP_063120895.1
    XP_063120896.1
    XP_063120897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134340.2 → NP_599167.2  dual specificity protein kinase CLK3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9
      Conserved Domains (1) summary
      cd14214
      Location:142 → 472
      PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      67048121..67063192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243146.5 → XP_006243208.1  dual specificity protein kinase CLK3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UQV5
      Related
      ENSRNOP00000061691.3, ENSRNOT00000068108.4
      Conserved Domains (2) summary
      PHA03247
      Location:29 → 162
      PHA03247; large tegument protein UL36; Provisional
      cd14214
      Location:292 → 622
      PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

    2. XM_063264827.1 → XP_063120897.1  dual specificity protein kinase CLK3 isoform X2

      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9

    3. XM_063264825.1 → XP_063120895.1  dual specificity protein kinase CLK3 isoform X2

      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9

    4. XM_063264824.1 → XP_063120894.1  dual specificity protein kinase CLK3 isoform X2

      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9

    5. XM_039080747.2 → XP_038936675.1  dual specificity protein kinase CLK3 isoform X2

      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9
      Conserved Domains (1) summary
      cd14214
      Location:142 → 472
      PKc_CLK3; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3

    6. XM_063264826.1 → XP_063120896.1  dual specificity protein kinase CLK3 isoform X2

      UniProtKB/Swiss-Prot
      Q63117, Q6IRK2
      UniProtKB/TrEMBL
      A0A8I6GM85, A6J4X9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63117.2 GenPept UniProtKB/Swiss-Prot:Q63117

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