Maob monoamine oxidase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maobprovided by RGD
Official Full Name: monoamine oxidase Bprovided by RGD
Primary source: RGD:3041
See related: EnsemblRapid:ENSRNOG00000029778 AllianceGenome:RGD:3041
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables flavin adenine dinucleotide binding activity; identical protein binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Involved in several processes, including negative regulation of serotonin secretion; phenylethylamine catabolic process; and positive regulation of dopamine metabolic process. Located in dendrite; mitochondrial outer membrane; and neuronal cell body. Biomarker of Parkinson's disease and cholestasis. Human ortholog(s) of this gene implicated in Alzheimer's disease and Parkinson's disease. Orthologous to human MAOB (monoamine oxidase B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 548.4), Lung (RPKM 237.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (8490405..8594065)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (5907327..6010996)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (6430694..6533520)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
Title: Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin.
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Title: Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis.
Monoamine Oxidase-B Inhibition Facilitates alpha-Synuclein Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat Models of Parkinson's Disease.
Title: Monoamine Oxidase-B Inhibition Facilitates α-Synuclein Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat Models of Parkinson's Disease.
Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm
Title: A spectrophotometric assay for monoamine oxidase activity with 2, 4-dinitrophenylhydrazine as a derivatized reagent.
Monoamine oxidase B is increased in prefrontal cortex following ethanol administration.
Title: Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats.
investigation of topological orientation of MAO-B (and MAO-A) in liver mitochondrial membranes
Title: Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase
Title: Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
Title: Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
These results suggest that LPS induces chronic wounds via elevated MAO/B-mediated increases in H(2)O(2) and TNF-alpha activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss.
Title: Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model.
localization of monoamine oxidase type B in liver; no MAOB was found in endothelial cells, hepatic stellate cells, or Kupffer cells; MAOB was localized to the mitochondrial outer membrane of hepatocytes
Title: Immunocytochemical localization of monoamine oxidase type B in rat liver.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129056 (e-PCR)
- UniSTS:212364

RH142419 (e-PCR)
- UniSTS:231666

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aliphatic amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables primary methylamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary methylamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables primary methylamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables primary methylamine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phenylethylamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to aluminum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amine oxidase [flavin-containing] B

Names: MAO-B; monoamine oxidase type B

NP_037330.1

EC 1.4.3.21

EC 1.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013198.1 → NP_037330.1 amine oxidase [flavin-containing] B

See identical proteins and their annotated locations for NP_037330.1

Status: PROVISIONAL

Source sequence(s)

M23601

UniProtKB/Swiss-Prot

P19643, Q5EBB5

UniProtKB/TrEMBL

A6JZX1

Related

ENSRNOP00000101104.1, ENSRNOT00000164539.1

Conserved Domains (2) summary

COG1231
Location:5 → 451

YobN; Monoamine oxidase [Amino acid transport and metabolism]

pfam13450
Location:9 → 75

NAD_binding_8; NAD(P)-binding Rossmann-like domain