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    Thg1l tRNA-histidine guanylyltransferase 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303067, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thg1lprovided by RGD
    Official Full Name
    tRNA-histidine guanylyltransferase 1-likeprovided by RGD
    Primary source
    RGD:1359513
    See related
    EnsemblRapid:ENSRNOG00000005539 AllianceGenome:RGD:1359513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including guanyl-nucleotide exchange factor activity; magnesium ion binding activity; and purine ribonucleoside triphosphate binding activity. Predicted to be involved in several processes, including protein homotetramerization; stress-induced mitochondrial fusion; and tRNA modification. Predicted to be located in mitochondrion. Predicted to be part of transferase complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 28. Orthologous to human THG1L (tRNA-histidine guanylyltransferase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 44.1), Thymus (RPKM 41.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thg1l in Genome Data Viewer
    Location:
    10q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30889259..30897903, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30387929..30396579, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31043647..31052092, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene clathrin interactor 1 Neighboring gene LSM11, U7 small nuclear RNA associated Neighboring gene SRY-box transcription factor 30 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α. Hickey FB, et al. J Am Soc Nephrol, 2011 Aug. PMID 21784897, Free PMC Article
    2. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Hyde SJ, et al. Proc Natl Acad Sci U S A, 2010 Nov 23. PMID 21059936, Free PMC Article
    3. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA guanylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA guanylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress-induced mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-induced mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-induced mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 5'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable tRNA(His) guanylyltransferase
    NP_001013988.1
    XP_017452739.1
    XP_017452740.1
    XP_063125038.1
    XP_063125039.1
    XP_063125040.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013966.1 → NP_001013988.1  probable tRNA(His) guanylyltransferase

      See identical proteins and their annotated locations for NP_001013988.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087596
      UniProtKB/Swiss-Prot
      Q5M965
      UniProtKB/TrEMBL
      A0A8L2Q363, A6HDQ4
      Related
      ENSRNOP00000007917.6, ENSRNOT00000007917.9
      Conserved Domains (1) summary
      COG4021
      Location:31 → 291
      Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      30889259..30897903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268970.1 → XP_063125040.1  probable tRNA(His) guanylyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLA0, A6HDQ5

    2. XM_063268969.1 → XP_063125039.1  probable tRNA(His) guanylyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLA0, A6HDQ5
      Related
      ENSRNOP00000078306.1, ENSRNOT00000099031.2

    3. XM_017597251.3 → XP_017452740.1  probable tRNA(His) guanylyltransferase isoform X3

    4. XM_063268968.1 → XP_063125038.1  probable tRNA(His) guanylyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLA0, A6HDQ5

    5. XM_017597250.3 → XP_017452739.1  probable tRNA(His) guanylyltransferase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M965.1 GenPept UniProtKB/Swiss-Prot:Q5M965

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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