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    Kif21b kinesin family member 21B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289397, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Kif21bprovided by RGD
    Official Full Name
    kinesin family member 21Bprovided by RGD
    Primary source
    RGD:1306206
    See related
    EnsemblRapid:ENSRNOG00000008471 AllianceGenome:RGD:1306206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in regulation of postsynaptic membrane neurotransmitter receptor levels and retrograde dendritic transport. Predicted to act upstream of or within corpus callosum development. Predicted to be located in cytoskeleton; dendrite cytoplasm; and growth cone. Predicted to be part of kinesin complex. Predicted to be active in glutamatergic synapse; microtubule; and postsynaptic endosome. Orthologous to human KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 64.7), Spleen (RPKM 63.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif21b in Genome Data Viewer
    Location:
    13q13
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50127842..50177822)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47576129..47626112)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52976505..53026750)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene uncharacterized LOC134481564 Neighboring gene maestro heat-like repeat family member 3 Neighboring gene mitochondrial ribosomal protein L42 like 1 Neighboring gene uncharacterized LOC120096257 Neighboring gene innate immunity activator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. Ghiretti AE, et al. Neuron, 2016 Nov 23. PMID 27817978, Free PMC Article
    2. Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. Chan WM, et al. BMC Genet, 2007 May 18. PMID 17511870, Free PMC Article
    3. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF21B is a molecular regulator of activity-dependent trafficking and microtubule dynamicity in dendrites.
      Title: Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189181

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde dendritic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF21B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415800.1 → NP_001402729.1  kinesin-like protein KIF21B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AJU2
      Related
      ENSRNOP00000082225.2, ENSRNOT00000098466.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50127842..50177822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249856.5 → XP_006249918.1  kinesin-like protein KIF21B isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7Q9, A0A8I6G960
      Related
      ENSRNOP00000074306.2, ENSRNOT00000090599.3
      Conserved Domains (8) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1304 → 1613
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1303 → 1611
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:657 → 791
      PKK; Polo kinase kinase
      pfam16034
      Location:675 → 803
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1310 → 1344
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:961 → 1097
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. XM_006249857.5 → XP_006249919.1  kinesin-like protein KIF21B isoform X6

      UniProtKB/TrEMBL
      A0A8I6AJU2
      Conserved Domains (8) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1303 → 1612
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1302 → 1610
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:656 → 790
      PKK; Polo kinase kinase
      pfam16034
      Location:674 → 802
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1309 → 1343
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:960 → 1096
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    3. XM_063272196.1 → XP_063128266.1  kinesin-like protein KIF21B isoform X1

      UniProtKB/TrEMBL
      A0A8I6G960
      Related
      ENSRNOP00000011324.7, ENSRNOT00000011324.9

    4. XM_006249854.5 → XP_006249916.1  kinesin-like protein KIF21B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJU2
      Conserved Domains (8) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1291 → 1599
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1290 → 1598
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:657 → 791
      PKK; Polo kinase kinase
      pfam16034
      Location:675 → 803
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1297 → 1331
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:961 → 1097
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    5. XM_063272197.1 → XP_063128267.1  kinesin-like protein KIF21B isoform X2

      UniProtKB/Swiss-Prot
      F1M5N7
      UniProtKB/TrEMBL
      A0A8I6AJU2
      Related
      ENSRNOP00000094546.2, ENSRNOT00000105337.2

    6. XM_063272198.1 → XP_063128268.1  kinesin-like protein KIF21B isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJU2

    7. XM_039090608.2 → XP_038946536.1  kinesin-like protein KIF21B isoform X7

      UniProtKB/TrEMBL
      A0A8I6AJU2
      Conserved Domains (3) summary
      COG1196
      Location:381 → 1083
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01372
      Location:7 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cd22262
      Location:926 → 1007
      Rcc_KIF21B; regulatory coiled-coil domain found in kinesin-like protein KIF21B

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105990.2: Suppressed sequence

      Description
      NM_001105990.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1M5N7.2 GenPept UniProtKB/Swiss-Prot:F1M5N7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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