Cenpc centromere protein C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpcprovided by RGD
Official Full Name: centromere protein Cprovided by RGD
Primary source: RGD:1303061
See related: EnsemblRapid:ENSRNOG00000021776 AllianceGenome:RGD:1303061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cenpc1
Summary: Predicted to enable centromeric DNA binding activity and identical protein binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; kinetochore assembly; and spindle attachment to meiosis I kinetochore. Predicted to be located in chromosome, centromeric region; midbody; and nuclear body. Predicted to be part of inner kinetochore. Human ortholog(s) of this gene implicated in CREST syndrome and liver cirrhosis. Orthologous to human CENPC (centromere protein C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 199.7), Spleen (RPKM 145.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (22342910..22401522)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21988067..22046732)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23611909..23670314)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables centromeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in spindle attachment to meiosis I kinetochore	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centromere protein C

Names: centromere autoantigen C; centromere protein C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004098.2 → NP_001004098.2 centromere protein C isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

E9PSW8, Q66LH7

Related

ENSRNOP00000032986.4, ENSRNOT00000031074.7
NM_001433916.1 → NP_001420845.1 centromere protein C isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

Q66LH7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

22342910..22401522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091875.2 → XP_038947803.1 centromere protein C isoform X1

Conserved Domains (3) summary

pfam15620
Location:284 → 533

CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region

pfam15622
Location:7 → 279

CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

cl40423
Location:808 → 877

cupin_RmlC-like; RmlC-like cupin superfamily
XM_063273074.1 → XP_063129144.1 centromere protein C isoform X2

UniProtKB/TrEMBL

A0A8I6ACV2