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    Card6 caspase recruitment domain family, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Card6provided by RGD
    Official Full Name
    caspase recruitment domain family, member 6provided by RGD
    Primary source
    RGD:1305805
    See related
    EnsemblRapid:ENSRNOG00000001271 AllianceGenome:RGD:1305805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of apoptotic process. Orthologous to human CARD6 (caspase recruitment domain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 129.9), Thymus (RPKM 127.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Card6 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55921832..55934388, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (54194343..54206902, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54810676..54824050, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene complement C7 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395067.1 → NP_001381996.1  caspase recruitment domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GLM7, A6KGD6, D3ZVT3
      Related
      ENSRNOP00000032723.4, ENSRNOT00000039057.5
      Conserved Domains (3) summary
      PHA03378
      Location:929 → 1082
      PHA03378; EBNA-3B; Provisional
      cd01671
      Location:11 → 79
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam05109
      Location:806 → 1123
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      55921832..55934388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760761.4 → XP_008758983.1  caspase recruitment domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_008758983.1

      UniProtKB/TrEMBL
      A0A8I6GLM7, A6KGD6, D3ZVT3
      Related
      ENSRNOP00000095462.2, ENSRNOT00000108176.2
      Conserved Domains (3) summary
      PHA03378
      Location:929 → 1082
      PHA03378; EBNA-3B; Provisional
      cd01671
      Location:11 → 79
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam05109
      Location:806 → 1123
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_017590717.3 → XP_017446206.1  caspase recruitment domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLM7, A6KGD6, D3ZVT3
      Conserved Domains (3) summary
      PHA03378
      Location:929 → 1082
      PHA03378; EBNA-3B; Provisional
      cd01671
      Location:11 → 79
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam05109
      Location:806 → 1123
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106413.1: Suppressed sequence

      Description
      NM_001106413.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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