Abcb6 ATP binding cassette subfamily B member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb6provided by RGD
Official Full Name: ATP binding cassette subfamily B member 6provided by RGD
Primary source: RGD:71077
See related: EnsemblRapid:ENSRNOG00000018697 AllianceGenome:RGD:71077
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MTABC3
Summary: Predicted to enable several functions, including ABC-type heme transporter activity; ATP binding activity; and ATP hydrolysis activity. Involved in intracellular copper ion homeostasis. Located in early endosome membrane; endolysosome membrane; and late endosome membrane. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 175.7), Liver (RPKM 158.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (84117222..84125939, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (76668554..76677263, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (82373950..82382228, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In summary, these results demonstrate that rAbcb6 is a glycosylated protein targeted to intracellular vesicular membranes and suggest involvement of rAbcb6 in transition metal homeostasis.
Title: Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6.

Submit: New GeneRIF Correction

General gene information

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Markers

BE098749 (e-PCR)
- UniSTS:245291

RH103428 (e-PCR)
- UniSTS:97753

BQ193984 (e-PCR)
- UniSTS:261868

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type heme transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type heme transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables tetrapyrrole binding	ISO Inferred from Sequence Orthology more info
enables tetrapyrrole binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of cadmium ion	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in heme B biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme metabolic process	ISO Inferred from Sequence Orthology more info
involved_in heme metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in heme transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in melanosome assembly	ISO Inferred from Sequence Orthology more info
involved_in melanosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in porphyrin-containing compound biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in porphyrin-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in porphyrin-containing compound metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in tetrapyrrole metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tetrapyrrole metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endolysosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
located_in endolysosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial envelope	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-binding cassette sub-family B member 6

Names: ABC-type heme transporter ABCB6; ATP-binding cassette sub-family B member 6, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 6; ATP-binding cassette, subfamily B (MDR/TAP), member 6; mammalian mitochondrial ABC protein 3; ubiquitously-expressed mammalian ABC half transporter

NP_542149.1

EC 7.6.2.5

XP_038938899.1

EC 7.6.2.5

XP_038938900.1

EC 7.6.2.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080582.1 → NP_542149.1 ATP-binding cassette sub-family B member 6

See identical proteins and their annotated locations for NP_542149.1

Status: PROVISIONAL

Source sequence(s)

AJ003004

UniProtKB/Swiss-Prot

O70595

UniProtKB/TrEMBL

A0A0G2K4U1, A6JVY6

Related

ENSRNOP00000025627.3, ENSRNOT00000025627.8

Conserved Domains (4) summary

cd03253
Location:590 → 825

ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C

COG5265
Location:329 → 823

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]

pfam16185
Location:6 → 255

MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region

cl00549
Location:277 → 544

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

84117222..84125939 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082972.2 → XP_038938900.1 ATP-binding cassette sub-family B member 6 isoform X2

Conserved Domains (1) summary

COG5265
Location:41 → 535

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
XM_039082971.2 → XP_038938899.1 ATP-binding cassette sub-family B member 6 isoform X1

UniProtKB/TrEMBL

A0A0G2K4U1

Conserved Domains (3) summary

cd18581
Location:268 → 564

ABC_6TM_ABCB6; Six-transmembrane helical domain of the ATP-binding cassette subfamily B member 6, mitochondrial

pfam16185
Location:6 → 255

MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region

cl38936
Location:590 → 752

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases