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    Zc3h12c zinc finger CCCH type containing 12C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315658, updated on 4-Jan-2025

    Summary

    Official Symbol
    Zc3h12cprovided by RGD
    Official Full Name
    zinc finger CCCH type containing 12Cprovided by RGD
    Primary source
    RGD:1565078
    See related
    EnsemblRapid:ENSRNOG00000012470 AllianceGenome:RGD:1565078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565078
    Summary
    Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12C (zinc finger CCCH-type containing 12C). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 108.2), Adrenal (RPKM 88.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zc3h12c in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (61340446..61404932, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (52443791..52508643, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (56639439..56696968, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene radixin Neighboring gene ribosomal protein S19, pseudogene 12 Neighboring gene microRNA 6329 Neighboring gene uncharacterized LOC120094154 Neighboring gene uncharacterized LOC134479974 Neighboring gene uncharacterized LOC120094155 Neighboring gene uncharacterized LOC134480051

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable ribonuclease ZC3H12C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108146.1NP_001101616.1  probable ribonuclease ZC3H12C

      See identical proteins and their annotated locations for NP_001101616.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A8I5XWR9, A6J4I4, D3ZSI6
      Related
      ENSRNOP00000016638.5, ENSRNOT00000016637.8
      Conserved Domains (1) summary
      pfam11977
      Location:245401
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      61340446..61404932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081457.2XP_038937385.1  probable ribonuclease ZC3H12C isoform X3

      UniProtKB/TrEMBL
      A0A8I5XWR9
    2. XM_006243073.5XP_006243135.1  probable ribonuclease ZC3H12C isoform X1

      UniProtKB/TrEMBL
      A0A0G2K000, A0A8I5XWR9
      Related
      ENSRNOP00000078052.2, ENSRNOT00000111817.2
      Conserved Domains (1) summary
      pfam11977
      Location:264420
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
    3. XM_063265460.1XP_063121530.1  probable ribonuclease ZC3H12C isoform X2

      UniProtKB/TrEMBL
      A0A8I5XWR9, A0A8I5ZQ72
      Related
      ENSRNOP00000080211.1, ENSRNOT00000102146.2