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    Atp13a3 ATPase 13A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 678704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp13a3provided by RGD
    Official Full Name
    ATPase 13A3provided by RGD
    Primary source
    RGD:1590881
    See related
    EnsemblRapid:ENSRNOG00000066681 AllianceGenome:RGD:1590881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable P-type transmembrane transporter activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to be located in early endosome membrane; late endosome membrane; and recycling endosome membrane. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 236.1), Kidney (RPKM 231.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp13a3 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83860725..83946899)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (70364998..70442005)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73936750..73963852)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095682 Neighboring gene uncharacterized LOC120095571 Neighboring gene uncharacterized LOC120095683 Neighboring gene ribosomal protein S26, pseudogene 13 Neighboring gene glycoprotein V (platelet) Neighboring gene leucine rich repeat containing 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP13A3 is a major component of the enigmatic mammalian polyamine transport system. Hamouda NN, et al. J Biol Chem, 2021 Jan-Jun. PMID 33310703, Free PMC Article
    2. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. Lindhurst MJ, et al. N Engl J Med, 2011 Aug 18. PMID 21793738, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polyamine-transporting ATPase 13A3
    Names
    ATPase type 13A3
    probable cation-transporting ATPase 13A3
    NP_001102839.2
    XP_038944543.1
    XP_038944544.1
    XP_038944545.1
    XP_038944546.1
    XP_038944547.1
    XP_063126830.1
    XP_063126831.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109369.2 → NP_001102839.2  polyamine-transporting ATPase 13A3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AAY5, A6JRU7
      Related
      ENSRNOP00000089051.2, ENSRNOT00000098527.2
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      83860725..83946899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270760.1 → XP_063126830.1  polyamine-transporting ATPase 13A3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAY5, A0A8I6ADK9, A6JRU6

    2. XM_039088616.2 → XP_038944544.1  polyamine-transporting ATPase 13A3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAY5, A0A8I6ADK9, A6JRU6
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    3. XM_039088615.2 → XP_038944543.1  polyamine-transporting ATPase 13A3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAY5, A0A8I6ADK9, A6JRU6
      Related
      ENSRNOP00000090335.1, ENSRNOT00000108436.2
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    4. XM_063270761.1 → XP_063126831.1  polyamine-transporting ATPase 13A3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAY5

    5. XM_039088617.2 → XP_038944545.1  polyamine-transporting ATPase 13A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAY5
      Related
      ENSRNOP00000111054.1, ENSRNOT00000164180.1
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1115
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    6. XM_039088618.2 → XP_038944546.1  polyamine-transporting ATPase 13A3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAY5
      Conserved Domains (1) summary
      TIGR01657
      Location:14 → 1142
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

    7. XM_039088619.2 → XP_038944547.1  polyamine-transporting ATPase 13A3 isoform X5

      Conserved Domains (1) summary
      TIGR01657
      Location:1 → 852
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    Nucleotide Protein Strain
    Heading Accession and Version

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