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    Rspo1 R-spondin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rspo1provided by RGD
    Official Full Name
    R-spondin 1provided by RGD
    Primary source
    RGD:1565558
    See related
    EnsemblRapid:ENSRNOG00000009656 AllianceGenome:RGD:1565558
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565558
    Summary
    Predicted to enable G protein-coupled receptor binding activity and heparin binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of protein phosphorylation; and regulation of receptor internalization. Predicted to act upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Predicted to be located in nucleus. Predicted to be active in extracellular space. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 33.9), Lung (RPKM 32.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rspo1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142536162..142557611)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137251629..137273273)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142986526..143007847)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 8 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene uncharacterized LOC108351029 Neighboring gene G protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats. Li JY, et al. Endocrinology, 2014 Feb. PMID 24280058, Free PMC Article
    2. R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Kamata T, et al. Biochim Biophys Acta, 2004 Jan 5. PMID 14732490
    3. R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5. Ruffner H, et al. PLoS One, 2012. PMID 22815884, Free PMC Article
    4. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. Carmon KS, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21693646, Free PMC Article
    5. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Binnerts ME, et al. Proc Natl Acad Sci U S A, 2007 Sep 11. PMID 17804805, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis.
      Title: LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of male germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    R-spondin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107980.1 → NP_001101450.1  R-spondin-1 precursor

      See identical proteins and their annotated locations for NP_001101450.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS66, D3ZBD1
      Conserved Domains (3) summary
      cd00064
      Location:100 → 142
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam15913
      Location:42 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich
      cl15278
      Location:151 → 216
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      142536162..142557611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287752.1 → XP_063143822.1  R-spondin-1 isoform X1

      UniProtKB/TrEMBL
      A6IS66, D3ZBD1
      Related
      ENSRNOP00000098861.1, ENSRNOT00000158619.1

    2. XM_008764019.4 → XP_008762241.1  R-spondin-1 isoform X1

      See identical proteins and their annotated locations for XP_008762241.1

      UniProtKB/TrEMBL
      A6IS66, D3ZBD1
      Related
      ENSRNOP00000012811.4, ENSRNOT00000012811.7
      Conserved Domains (3) summary
      cd00064
      Location:100 → 142
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam15913
      Location:42 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich
      cl15278
      Location:151 → 216
      TSP_1; Thrombospondin type 1 domain

    3. XM_039110013.2 → XP_038965941.1  R-spondin-1 isoform X2

      Conserved Domains (2) summary
      pfam15913
      Location:23 → 78
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:84 → 139
      TSP1_spondin; Spondin-like TSP1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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