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    Tle2 TLE family member 2, transcriptional corepressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tle2provided by RGD
    Official Full Name
    TLE family member 2, transcriptional corepressorprovided by RGD
    Primary source
    RGD:1306665
    See related
    EnsemblRapid:ENSRNOG00000005874 AllianceGenome:RGD:1306665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Predicted to be located in focal adhesion and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 64.4), Adrenal (RPKM 45.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tle2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8769815..8789493, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8119049..8135385, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10988536..11003957, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551996 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene G protein subunit alpha 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. Arce L, et al. BMC Cancer, 2009 May 21. PMID 19460168, Free PMC Article
    2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124808

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 2
    Names
    transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 2 homolog
    transducin-like enhancer of split 2, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039013.1 → NP_001034102.1  transducin-like enhancer protein 2

      See identical proteins and their annotated locations for NP_001034102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100652
      UniProtKB/TrEMBL
      A0A8I6A8Q2, Q496Z7
      Related
      ENSRNOP00000057991.2, ENSRNOT00000061279.4
      Conserved Domains (4) summary
      COG2319
      Location:408 → 694
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:413 → 452
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:409 → 693
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8769815..8789493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078654.2 → XP_038934582.1  transducin-like enhancer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K109, A6K868
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:479 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039078653.2 → XP_038934581.1  transducin-like enhancer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K109, A6K868
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:479 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039078660.2 → XP_038934588.1  transducin-like enhancer protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K109
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 344
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:436 → 475
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:432 → 716
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_039078656.2 → XP_038934584.1  transducin-like enhancer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K109, A6K868
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:479 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_039078657.2 → XP_038934585.1  transducin-like enhancer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K109, A6K868
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:479 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_039078658.2 → XP_038934586.1  transducin-like enhancer protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K109
      Related
      ENSRNOP00000071657.2, ENSRNOT00000084006.3
      Conserved Domains (4) summary
      PHA03247
      Location:268 → 457
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:482 → 521
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 151
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:478 → 762
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_039078659.2 → XP_038934587.1  transducin-like enhancer protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K109
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 446
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:471 → 510
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:467 → 751
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_063263177.1 → XP_063119247.1  transducin-like enhancer protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K109, A6K867

    9. XM_063263180.1 → XP_063119250.1  transducin-like enhancer protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K109

    10. XM_063263178.1 → XP_063119248.1  transducin-like enhancer protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K109, A6K867

    11. XM_063263181.1 → XP_063119251.1  transducin-like enhancer protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K109

    12. XM_006240893.4 → XP_006240955.1  transducin-like enhancer protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K109
      Conserved Domains (4) summary
      COG2319
      Location:454 → 740
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:459 → 498
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:455 → 739
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_006240889.4 → XP_006240951.1  transducin-like enhancer protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006240951.1

      UniProtKB/TrEMBL
      A0A0G2K109, A6K867
      Related
      ENSRNOP00000086408.2, ENSRNOT00000115215.2
      Conserved Domains (4) summary
      COG2319
      Location:455 → 741
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:460 → 499
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:456 → 740
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_063263179.1 → XP_063119249.1  transducin-like enhancer protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K109

    15. XM_039078664.2 → XP_038934592.1  transducin-like enhancer protein 2 isoform X10

      Conserved Domains (2) summary
      PHA03307
      Location:224 → 361
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    16. XM_039078661.2 → XP_038934589.1  transducin-like enhancer protein 2 isoform X9

      Conserved Domains (2) summary
      PHA03307
      Location:224 → 361
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RNA

    1. XR_005486568.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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