Hint2 histidine triad nucleotide binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hint2provided by RGD
Official Full Name: histidine triad nucleotide binding protein 2provided by RGD
Primary source: RGD:1308910
See related: EnsemblRapid:ENSRNOG00000015866 AllianceGenome:RGD:1308910
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity. Predicted to act upstream of or within lipid catabolic process and negative regulation of peptidyl-lysine acetylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 851.5), Liver (RPKM 539.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62700383..62702638, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57904613..57906868, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59150344..59152599, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT2

Names: histidine triad nucleotide-binding protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107955.2 → NP_001101425.2 adenosine 5'-monophosphoramidase HINT2

See identical proteins and their annotated locations for NP_001101425.2

Status: VALIDATED

Source sequence(s)

BI282127, JAXUCZ010000005

UniProtKB/TrEMBL

A6IJ43

Related

ENSRNOP00000021387.5, ENSRNOT00000021387.7

Conserved Domains (1) summary

cd01276
Location:53 → 155

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...