Leprot leptin receptor overlapping transcript [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Leprotprovided by RGD
Official Full Name: leptin receptor overlapping transcriptprovided by RGD
Primary source: RGD:621034
See related: AllianceGenome:RGD:621034
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Obrgrp; Ob-Rgrp
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of signal transduction; and regulation of protein localization. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 350.1), Lung (RPKM 286.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (121405170..121417273)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (116289843..116301951)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (120498910..120511011)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OB-RGRP regulated the phosphorylation of JAK2 and STAT3 in primary rat adipocytes
Title: OB-RGRP regulates the phosphorylation of JAK2 and STAT3 in primary rat adipocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

D5Rhw23 (e-PCR)
- UniSTS:519042

RH129126 (e-PCR)
- UniSTS:212434

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leptin receptor gene-related protein

Names: OB-R gene-related protein; OB-receptor gene related protein (OB-RGRP); endospanin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020099.2 → NP_064484.1 leptin receptor gene-related protein

See identical proteins and their annotated locations for NP_064484.1

Status: PROVISIONAL

Source sequence(s)

BC062003

UniProtKB/Swiss-Prot

Q9JLS8

UniProtKB/TrEMBL

A0A8I6B3V3, A6JRN9

Conserved Domains (1) summary

pfam04133
Location:7 → 124

Vps55; Vacuolar protein sorting 55