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    Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkal1provided by RGD
    Official Full Name
    CDK5 regulatory subunit associated protein 1-like 1provided by RGD
    Primary source
    RGD:1310246
    See related
    EnsemblRapid:ENSRNOG00000072186 AllianceGenome:RGD:1310246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N6-threonylcarbomyladenosine methylthiotransferase activity. Predicted to act upstream of or within maintenance of translational fidelity and tRNA methylthiolation. Predicted to be located in rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; diabetic retinopathy; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 59.3), Thymus (RPKM 51.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkal1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (34927221..35479827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (34718701..35271276)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (36451031..37157882)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein L37-like 3 Neighboring gene uncharacterized LOC120097733 Neighboring gene uncharacterized LOC120097731 Neighboring gene U1 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. Brambillasca S, et al. J Biol Chem, 2012 Dec 7. PMID 23048041, Free PMC Article
    2. Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. Arragain S, et al. J Biol Chem, 2010 Sep 10. PMID 20584901, Free PMC Article
    3. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Peng D, et al. Sci Rep, 2017 Aug 18. PMID 28821857, Free PMC Article
    4. Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. Ohara-Imaizumi M, et al. PLoS One, 2010 Dec 9. PMID 21151568, Free PMC Article
    5. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. Wei FY, et al. J Clin Invest, 2011 Sep. PMID 21841312, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.
      Title: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N6-threonylcarbomyladenosine methylthiotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-threonylcarbomyladenosine methylthiotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within maintenance of translational fidelity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylthiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA methylthiolation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    threonylcarbamoyladenosine tRNA methylthiotransferase
    NP_001389100.1
    NP_001389101.1
    XP_063132663.1
    XP_063132664.1
    XP_063132666.1
    XP_063132667.1
    XP_063132668.1
    XP_063132669.1
    XP_063132670.1
    XP_063132671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402171.2 → NP_001389100.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J7N5, F1LV76, K9N0M9

    2. NM_001402172.2 → NP_001389101.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZT83
      Related
      ENSRNOP00000081920.1, ENSRNOT00000116835.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      34927221..35479827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276598.1 → XP_063132668.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X3

    2. XM_063276594.1 → XP_063132664.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

      UniProtKB/TrEMBL
      A6J7N5, F1LV76, K9N0M9

    3. XM_063276597.1 → XP_063132667.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2

      UniProtKB/TrEMBL
      A6J7N6

    4. XM_063276599.1 → XP_063132669.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X4

    5. XM_063276593.1 → XP_063132663.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

      UniProtKB/TrEMBL
      A6J7N5, F1LV76, K9N0M9

    6. XM_063276600.1 → XP_063132670.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X4

    7. XM_063276596.1 → XP_063132666.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1

      UniProtKB/TrEMBL
      A6J7N5, F1LV76, K9N0M9

    8. XM_063276601.1 → XP_063132671.1  threonylcarbamoyladenosine tRNA methylthiotransferase isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108413.1: Suppressed sequence

      Description
      NM_001108413.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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