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    Cndp1 carnosine dipeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cndp1provided by RGD
    Official Full Name
    carnosine dipeptidase 1provided by RGD
    Primary source
    RGD:1359493
    See related
    EnsemblRapid:ENSRNOG00000027739 AllianceGenome:RGD:1359493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 74.0), Uterus (RPKM 31.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cndp1 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80254499..80305845, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (77984886..78030837, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81466717..81512841, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482989 Neighboring gene zinc finger protein 407 Neighboring gene carnosine dipeptidase 2 Neighboring gene divergent protein kinase domain 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians. Chakkera HA, et al. Mol Genet Metab, 2011 Jun. PMID 21393041, Free PMC Article
    2. Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? results of a family-based study. Kiliś-Pstrusińska K, et al. Arch Med Res, 2010 Jul. PMID 20851293
    3. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, et al. J Biol Chem, 2003 Feb 21. PMID 12473676
    4. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. Veiga-da-Cunha M, et al. J Biol Chem, 2014 Jul 11. PMID 24891507, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC93742

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-Ala-His dipeptidase
    Names
    CNDP dipeptidase 1
    carnosine dipeptidase 1 (metallopeptidase M20 family)
    NP_001007688.1
    XP_008770357.1
    XP_038952698.1
    XP_063133361.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007687.2 → NP_001007688.1  beta-Ala-His dipeptidase

      See identical proteins and their annotated locations for NP_001007688.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q66HG3
      Related
      ENSRNOP00000034652.3, ENSRNOT00000034970.7
      Conserved Domains (2) summary
      PRK08201
      Location:16 → 481
      PRK08201; hypothetical protein; Provisional
      cd05676
      Location:13 → 481
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      80254499..80305845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277291.1 → XP_063133361.1  beta-Ala-His dipeptidase isoform X2

      Related
      ENSRNOP00000101885.1, ENSRNOT00000151240.1

    2. XM_039096770.2 → XP_038952698.1  beta-Ala-His dipeptidase isoform X3

      Conserved Domains (1) summary
      cd05676
      Location:13 → 426
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    3. XM_008772135.4 → XP_008770357.1  beta-Ala-His dipeptidase isoform X1

      See identical proteins and their annotated locations for XP_008770357.1

      UniProtKB/Swiss-Prot
      Q66HG3
      Conserved Domains (2) summary
      PRK08201
      Location:16 → 481
      PRK08201; hypothetical protein; Provisional
      cd05676
      Location:13 → 481
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HG3.1 GenPept UniProtKB/Swiss-Prot:Q66HG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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