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    Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 396527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ugt1a2provided by RGD
    Official Full Name
    UDP glucuronosyltransferase 1 family, polypeptide A2provided by RGD
    Primary source
    RGD:1549741
    See related
    EnsemblRapid:ENSRNOG00000018740 AllianceGenome:RGD:1549741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ugt1; Udpgt; UDPGT 1-2
    Summary
    Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Involved in animal organ regeneration; liver development; and response to organic cyclic compound. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 2015.6), Kidney (RPKM 841.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ugt1a2 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96239019..96256264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88791216..88808465)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95285592..95302822)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional enhancement of UDP-glucuronosyltransferase form 1A2 (UGT1A2) by nuclear factor I-A (NFI-A) in rat hepatocytes. Emi Y, et al. J Biochem, 2005 Sep. PMID 16169882
    2. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, et al. Pharm Res, 2005 Dec. PMID 16222444
    3. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18938141
    4. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR, et al. Drug Metab Dispos, 2002 Mar. PMID 11854140
    5. Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript. Sato H, et al. Biochem Biophys Res Commun, 1990 May 31. PMID 2112380

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flavonoid glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in vitamin D3 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 1-2
    Names
    B2
    UDP glucuronosyltransferase 1A2
    UDP glycosyltransferase 1 family polypeptide A2
    UGT1*0
    UGT1-02
    UGT1.2
    bilirubin specific
    bilirubin-specific UDPGT
    NP_958826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201423.2 → NP_958826.1  UDP-glucuronosyltransferase 1-2 precursor

      See identical proteins and their annotated locations for NP_958826.1

      Status: VALIDATED

      Source sequence(s)
      AC120922, AY435130
      UniProtKB/Swiss-Prot
      P20720, Q64636
      UniProtKB/TrEMBL
      F7EP24, Q6T5F2
      Related
      ENSRNOP00000062958.1, ENSRNOT00000063853.6
      Conserved Domains (2) summary
      PHA03392
      Location:261 → 507
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:28 → 524
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      96239019..96256264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20720.2 GenPept UniProtKB/Swiss-Prot:P20720

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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