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    Tm9sf2 transmembrane 9 superfamily member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm9sf2provided by RGD
    Official Full Name
    transmembrane 9 superfamily member 2provided by RGD
    Primary source
    RGD:1359230
    See related
    EnsemblRapid:ENSRNOG00000012751 AllianceGenome:RGD:1359230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein localization to membrane; regulation of heparan sulfate proteoglycan biosynthetic process; and sphingolipid metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 457.8), Liver (RPKM 410.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm9sf2 in Genome Data Viewer
    Location:
    15q25
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (105606082..105660715)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (99201556..99254054)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (108526341..108579268)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene uncharacterized LOC108352982 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene uncharacterized LOC134482164 Neighboring gene FKBP prolyl isomerase 3, pseudogene 2 Neighboring gene uncharacterized LOC134482165 Neighboring gene citramalyl-CoA lyase Neighboring gene uncharacterized LOC102555437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Ross ME, et al. Blood, 2003 Oct 15. PMID 12730115
    2. A novel Rab9 effector required for endosome-to-TGN transport. Díaz E, et al. J Cell Biol, 1997 Jul 28. PMID 9230071, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93724

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 9 superfamily member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005554.1 → NP_001005554.1  transmembrane 9 superfamily member 2 precursor

      See identical proteins and their annotated locations for NP_001005554.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081873
      UniProtKB/Swiss-Prot
      Q66HG5
      Conserved Domains (1) summary
      pfam02990
      Location:75 → 619
      EMP70; Endomembrane protein 70

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      105606082..105660715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274359.1 → XP_063130429.1  transmembrane 9 superfamily member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q66HG5

    2. XM_063274360.1 → XP_063130430.1  transmembrane 9 superfamily member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q66HG5
      Related
      ENSRNOP00000017211.5, ENSRNOT00000017211.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HG5.1 GenPept UniProtKB/Swiss-Prot:Q66HG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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