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    Zfp422 zinc finger protein 422 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp422provided by RGD
    Official Full Name
    zinc finger protein 422provided by RGD
    Primary source
    RGD:620229
    See related
    EnsemblRapid:ENSRNOG00000013379 AllianceGenome:RGD:620229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kox15; Znf22; Krox-25
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human ZNF22 (zinc finger protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 93.2), Heart (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp422 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (151558254..151565730, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149885805..149893287, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148757362..148761594, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily D member 15B Neighboring gene transfer RNA cysteine (anticodon GCA) 29 Neighboring gene Ras association domain family member 4 Neighboring gene DEPP autophagy regulator 1 Neighboring gene transmembrane protein 72

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental expression pattern and DNA-binding properties of the zinc finger transcription factor Krox-26. Teo W, et al. Connect Tissue Res, 2003. PMID 12952191
    2. Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25. Lee SK, et al. Genomics, 2004 Feb. PMID 14706453
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105332

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in odontogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 22
    Names
    krueppel-type zinc finger protein Krox-25
    zinc finger protein 22 (KOX 15)
    zinc finger protein Krox-25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012745.1 → NP_001012763.1  zinc finger protein 22

      See identical proteins and their annotated locations for NP_001012763.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090354
      UniProtKB/Swiss-Prot
      Q5EAN1, Q9ERU2
      UniProtKB/TrEMBL
      A6IL24
      Related
      ENSRNOP00000076367.1, ENSRNOT00000097804.2
      Conserved Domains (2) summary
      COG5048
      Location:53 → 192
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      151558254..151565730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107733.2 → XP_038963661.1  zinc finger protein 22 isoform X1

      UniProtKB/Swiss-Prot
      Q5EAN1, Q9ERU2
      UniProtKB/TrEMBL
      A6IL24
      Related
      ENSRNOP00000018050.4, ENSRNOT00000018050.6
      Conserved Domains (2) summary
      COG5048
      Location:53 → 192
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006237189.5 → XP_006237251.1  zinc finger protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006237251.1

      UniProtKB/Swiss-Prot
      Q5EAN1, Q9ERU2
      UniProtKB/TrEMBL
      A6IL24
      Conserved Domains (2) summary
      COG5048
      Location:53 → 192
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006237187.5 → XP_006237249.1  zinc finger protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006237249.1

      UniProtKB/Swiss-Prot
      Q5EAN1, Q9ERU2
      UniProtKB/TrEMBL
      A6IL24
      Conserved Domains (2) summary
      COG5048
      Location:53 → 192
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006237190.5 → XP_006237252.1  zinc finger protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006237252.1

      UniProtKB/Swiss-Prot
      Q5EAN1, Q9ERU2
      UniProtKB/TrEMBL
      A6IL24
      Conserved Domains (2) summary
      COG5048
      Location:53 → 192
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:113 → 133
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERU2.2 GenPept UniProtKB/Swiss-Prot:Q9ERU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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