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    Eras ES cell expressed Ras [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679682, updated on 9-Dec-2024

    Summary

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    Symbol
    Erasprovided by RGD
    Full Name
    ES cell expressed Rasprovided by RGD
    Primary source
    RGD:1585907
    See related
    EnsemblRapid:ENSRNOG00000042470 AllianceGenome:RGD:1585907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human ERAS (ES cell expressed Ras). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 2.8), Testes (RPKM 2.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eras in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17245915..17250301)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14573987..14578455)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15318215..15322601)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134484178 Neighboring gene histone deacetylase 6 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene ribosomal protein S19, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells. Nakhaei-Rad S, et al. J Biol Chem, 2016 Apr 15. PMID 26884329, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings indicate that ERAS is important to maintain quiescence in HSCs.
      Title: The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase ERas
    NP_001102845.1
    XP_017457644.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109375.1 → NP_001102845.1  GTPase ERas

      See identical proteins and their annotated locations for NP_001102845.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474078
      UniProtKB/TrEMBL
      A6KP62, D3ZTE4
      Conserved Domains (2) summary
      smart00010
      Location:40 → 201
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04139
      Location:42 → 201
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    2. NM_001434382.1 → NP_001421311.1  GTPase ERas

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KP62, D3ZTE4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17245915..17250301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602155.3 → XP_017457644.1  GTPase ERas isoform X1

      Related
      ENSRNOP00000047699.3, ENSRNOT00000042140.5
      Conserved Domains (2) summary
      smart00010
      Location:40 → 201
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04139
      Location:42 → 201
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
    Nucleotide Protein Strain
    Heading Accession and Version

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