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    Fank1 fibronectin type III and ankyrin repeat domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fank1provided by RGD
    Official Full Name
    fibronectin type III and ankyrin repeat domains 1provided by RGD
    Primary source
    RGD:1304756
    See related
    EnsemblRapid:ENSRNOG00000018327 AllianceGenome:RGD:1304756
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of DNA-templated transcription and regulation of apoptotic process. Predicted to be located in several cellular components, including chromatin; ciliary basal body; and nucleoplasm. Predicted to be active in ciliary base and nucleus. Orthologous to human FANK1 (fibronectin type III and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 234.5), Lung (RPKM 16.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fank1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (198007496..198114790)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (188577512..188685501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (205842469..205954152)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene uncharacterized LOC134483951 Neighboring gene neuromedin U receptor 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway. Wang H, et al. Cell Mol Life Sci, 2011 Jun. PMID 20978819, Free PMC Article
    2. Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway. Ma W, et al. Cell Signal, 2016 Aug. PMID 27060496
    3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC95281

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary base IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type 3 and ankyrin repeat domains 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008347.1 → NP_001008348.1  fibronectin type 3 and ankyrin repeat domains 1 protein

      See identical proteins and their annotated locations for NP_001008348.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082095
      UniProtKB/Swiss-Prot
      Q66H07
      UniProtKB/TrEMBL
      A0A0H2UHP6, A6HX43
      Related
      ENSRNOP00000071170.3, ENSRNOT00000081610.3
      Conserved Domains (3) summary
      cd00063
      Location:12 → 104
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:148 → 240
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      198007496..198114790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263792.1 → XP_063119862.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP6

    2. XM_039078830.2 → XP_038934758.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHP6
      Related
      ENSRNOP00000111846.1, ENSRNOT00000124931.1
      Conserved Domains (3) summary
      cd00063
      Location:12 → 104
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:148 → 240
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006230439.5 → XP_006230501.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHP6, A0A8L2R406
      Conserved Domains (6) summary
      cd00063
      Location:12 → 104
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00204
      Location:171 → 298
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00023
      Location:144 → 174
      Ank; Ankyrin repeat
      pfam12796
      Location:148 → 240
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:244 → 298
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H07.1 GenPept UniProtKB/Swiss-Prot:Q66H07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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