Lamc2 laminin subunit gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamc2provided by RGD
Official Full Name: laminin subunit gamma 2provided by RGD
Primary source: RGD:621053
See related: EnsemblRapid:ENSRNOG00000002667 AllianceGenome:RGD:621053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in cell cortex; extracellular space; and perinuclear region of cytoplasm. Part of laminin-2 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 136.0), Heart (RPKM 95.4) and 5 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13q21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (67835199..67894694, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (65284664..65344164, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (70566643..70632126, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study aimed to identify genomic biomarkers for early and sensitive detection of renal papillary injury in rats; Timp1, Igf1, and Lamc2 exhibited the best prediction performance
Title: Toxicogenomic biomarkers for renal papillary injury in rats.
Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

LAMC2 (e-PCR)
- UniSTS:264093

RH140304 (e-PCR)
- UniSTS:222381

RH129354 (e-PCR)
- UniSTS:212661

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of laminin-5 complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: laminin subunit gamma-2

Names: lamimin, gamma 2; laminin, gamma 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100640.3 → NP_001094110.1 laminin subunit gamma-2 precursor

See identical proteins and their annotated locations for NP_001094110.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LRH4

Related

ENSRNOP00000037099.5, ENSRNOT00000036947.7

Conserved Domains (7) summary

cl14654
Location:1039 → 1159

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

smart00281
Location:245 → 370

LamB; Laminin B domain

COG0840
Location:769 → 1165

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:83 → 127

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00185
Location:445 → 481

TNFRSF; CRD2 [structural motif]

pfam00053
Location:139 → 184

Laminin_EGF; Laminin EGF domain

cl22855
Location:437 → 501

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

67835199..67894694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769603.4 → XP_008767825.1 laminin subunit gamma-2 isoform X1

See identical proteins and their annotated locations for XP_008767825.1

UniProtKB/TrEMBL

F1LRH4

Related

ENSRNOP00000099868.1, ENSRNOT00000131794.1

Conserved Domains (7) summary

cl14654
Location:1039 → 1159

V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains

smart00281
Location:245 → 370

LamB; Laminin B domain

COG0840
Location:769 → 1165

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:83 → 127

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00185
Location:445 → 481

TNFRSF; CRD2 [structural motif]

pfam00053
Location:139 → 184

Laminin_EGF; Laminin EGF domain

cl22855
Location:437 → 501

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)