Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrg1provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit gamma 1provided by RGD
Primary source: RGD:621732
See related: EnsemblRapid:ENSRNOG00000002360 AllianceGenome:RGD:621732
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity and GABA-A receptor activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Predicted to act upstream of or within chemical synaptic transmission. Part of receptor complex. Orthologous to human GABRG1 (gamma-aminobutyric acid type A receptor subunit gamma1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 249.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (37750292..37821651)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (37396217..37469606)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (39964502..40051306)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain alpha3 and gamma1 Subunits and Present Differential Functional and Pharmacological Properties.
Title: GABA(A) Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties.
Switching the intracellular domains of the gamma2 and gamma1 subunits substantiated this inference. Because this region determines post-synaptic localization, we hypothesize that GABAARs containing gamma1 and gamma2 use different mechanisms for synaptic clustering.
Title: GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.
Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors
Title: Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gabrg1 (e-PCR), detects polymorphism
- UniSTS:525654

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit gamma-1

Names: GABA(A) receptor subunit gamma-1; GABAAR subunit gamma-1; gamma-aminobutyric acid (GABA) A receptor, gamma 1; gamma-aminobutyric acid A receptor, gamma 1; gamma-aminobutyric acid type A receptor gamma 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080586.2 → NP_542153.1 gamma-aminobutyric acid receptor subunit gamma-1 precursor

See identical proteins and their annotated locations for NP_542153.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P23574

UniProtKB/TrEMBL

A0A8I6A4K4, A6JD87

Related

ENSRNOP00000098270.1, ENSRNOT00000120635.2

Conserved Domains (3) summary

TIGR00860
Location:66 → 462

LIC; Cation transporter family protein

pfam02931
Location:65 → 270

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:277 → 459

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region