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    Akr1c2 aldo-keto reductase family 1, member C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1c2provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member C2provided by RGD
    Primary source
    RGD:1311841
    See related
    EnsemblRapid:ENSRNOG00000029844 AllianceGenome:RGD:1311841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RAKg; Akr1c21
    Summary
    Predicted to enable several functions, including NADP binding activity; ketosteroid monooxygenase activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including cellular response to prostaglandin D stimulus; doxorubicin metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C2 (aldo-keto reductase family 1 member C2) and AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1093.1) and Kidney (RPKM 813.5) See more
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    Genomic context

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    See Akr1c2 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70669684..70717935, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65759778..65808013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69388337..69435160, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member E2 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 9 Neighboring gene aldo-keto reductase family 1, member C1 Neighboring gene aldo-keto reductase family 1 member C3-like 1 Neighboring gene aldo-keto reductase family 1, member C12-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme. Dhagat U, et al. Acta Crystallogr D Biol Crystallogr, 2010 Feb. PMID 20124700
    2. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. Faucher F, et al. J Mol Biol, 2007 Jun 1. PMID 17442338
    3. Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. Faucher F, et al. J Mol Biol, 2006 Dec 8. PMID 17034817
    4. Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family. Ishikura S, et al. Biol Pharm Bull, 2004 Dec. PMID 15577209
    5. Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. Hara A, et al. Biochem J, 1996 Jan 15. PMID 8573067, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lithocholic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lithocholic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to jasmonic acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to prostaglandin D stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in digestion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1 member C21
    Names
    17-alpha-HSD
    17-alpha-hydroxysteroid dehydrogenase
    3(17)alpha-hydroxysteroid dehydrogenase
    3(or 17)-alpha-hydroxysteroid dehydrogenase
    3-alpha-hydroxysteroid dehydrogenase
    aldo-keto reductase family 1, member C21
    NP_001013075.1
    XP_006254245.1
    XP_006254247.1
    XP_038951459.1
    XP_063132305.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013057.1 → NP_001013075.1  aldo-keto reductase family 1 member C21

      See identical proteins and their annotated locations for NP_001013075.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078957
      UniProtKB/Swiss-Prot
      Q6AYQ2
      UniProtKB/TrEMBL
      F1LQ80
      Conserved Domains (2) summary
      COG0656
      Location:8 → 312
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 293
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      70669684..70717935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254185.5 → XP_006254247.1  aldo-keto reductase family 1 member C21 isoform X2

      UniProtKB/TrEMBL
      F1LQ80
      Related
      ENSRNOP00000107623.1, ENSRNOT00000160073.1
      Conserved Domains (2) summary
      COG0656
      Location:8 → 291
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 272
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    2. XM_006254183.5 → XP_006254245.1  aldo-keto reductase family 1 member C21 isoform X1

      See identical proteins and their annotated locations for XP_006254245.1

      UniProtKB/TrEMBL
      A0A387KBL1, F1LQ80
      Related
      ENSRNOP00000045355.4, ENSRNOT00000051342.6
      Conserved Domains (1) summary
      cd19108
      Location:6 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    3. XM_063276235.1 → XP_063132305.1  aldo-keto reductase family 1 member C21 isoform X2

      UniProtKB/TrEMBL
      F1LQ80

    4. XM_039095531.2 → XP_038951459.1  aldo-keto reductase family 1 member C21 isoform X1

      UniProtKB/TrEMBL
      A0A387KBL1, F1LQ80
      Conserved Domains (1) summary
      cd19108
      Location:6 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYQ2.1 GenPept UniProtKB/Swiss-Prot:Q6AYQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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