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    Meiob meiosis specific with OB-fold [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meiobprovided by RGD
    Official Full Name
    meiosis specific with OB-foldprovided by RGD
    Primary source
    RGD:1583204
    See related
    EnsemblRapid:ENSRNOG00000014711 AllianceGenome:RGD:1583204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' DNA exonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 24.9), Liver (RPKM 6.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Meiob in Genome Data Viewer
    Location:
    10q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14336869..14369566)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13833170..13865684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14174645..14206026)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene hydroxyacyl glutathione hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination. Luo M, et al. Nat Commun, 2013. PMID 24240703, Free PMC Article
    2. MEIOB targets single-strand DNA and is necessary for meiotic recombination. Souquet B, et al. PLoS Genet, 2013. PMID 24068956, Free PMC Article
    3. Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. Kogo H, et al. J Hum Genet, 2010 May. PMID 20339383
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187464

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA 3'-5' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of meiotic recombination intermediates ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    meiosis-specific with OB domain-containing protein
    Names
    meiosis specific with OB domains
    uncharacterized protein C16orf73 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115033.1 → NP_001108505.1  meiosis-specific with OB domain-containing protein

      See identical proteins and their annotated locations for NP_001108505.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158604
      UniProtKB/Swiss-Prot
      B0BMX9
      UniProtKB/TrEMBL
      A0A8I5ZW82
      Related
      ENSRNOP00000082963.1, ENSRNOT00000094743.2
      Conserved Domains (2) summary
      cd04475
      Location:167 → 270
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165 → 408
      rpa1; replication factor-a protein 1 (rpa1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14336869..14369566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269834.1 → XP_063125904.1  meiosis-specific with OB domain-containing protein isoform X3

    2. XM_039086831.2 → XP_038942759.1  meiosis-specific with OB domain-containing protein isoform X4

      Conserved Domains (1) summary
      cd04475
      Location:167 → 270
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...

    3. XM_006246031.5 → XP_006246093.1  meiosis-specific with OB domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006246093.1

      UniProtKB/Swiss-Prot
      B0BMX9
      UniProtKB/TrEMBL
      A0A8I5ZW82
      Related
      ENSRNOP00000057290.2, ENSRNOT00000060551.4
      Conserved Domains (2) summary
      cd04475
      Location:167 → 270
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165 → 408
      rpa1; replication factor-a protein 1 (rpa1)

    4. XM_039086830.2 → XP_038942758.1  meiosis-specific with OB domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A6HCX5
      Conserved Domains (2) summary
      cd04475
      Location:45 → 148
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:43 → 286
      rpa1; replication factor-a protein 1 (rpa1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BMX9.1 GenPept UniProtKB/Swiss-Prot:B0BMX9

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