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    Lcat lecithin cholesterol acyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcatprovided by RGD
    Official Full Name
    lecithin cholesterol acyltransferaseprovided by RGD
    Primary source
    RGD:2993
    See related
    EnsemblRapid:ENSRNOG00000019573 AllianceGenome:RGD:2993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity. Involved in several processes, including aflatoxin metabolic process; cholesterol metabolic process; and response to copper ion. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Used to study end stage renal disease; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1462.7) and Brain (RPKM 58.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lcat in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50744598..50748064, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33834748..33838214, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37913333..37916799, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like Neighboring gene proteasome 20S subunit beta 10 Neighboring gene solute carrier family 12 member 4 Neighboring gene uncharacterized LOC120098640 Neighboring gene dipeptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reversible inhibition of LCAT by penicillins. Kinetic and mechanistic investigations. Bojesen E. Scand J Clin Lab Invest Suppl, 1978. PMID 746355
    2. Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat. Meroni G, et al. Nucleic Acids Res, 1990 Sep 11. PMID 2402469, Free PMC Article
    3. Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains. Zhao Y, et al. Biochemistry, 2003 Dec 2. PMID 14636062
    4. Isolation and specificity of rat lecithin: cholesterol acyltransferase: comparison with the human enzyme using reassembled high-density lipoproteins containing ether analogs of phosphatidylcholine. Pownall HJ, et al. Biochim Biophys Acta, 1985 Mar 6. PMID 3918579
    5. Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. Sangeetha T, et al. J Pharm Pharmacol, 2006 May. PMID 16640830

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108718

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables apolipoprotein A-I binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables apolipoprotein A-I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine-sterol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine-sterol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylcholine-sterol O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine-sterol O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables platelet-activating factor acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-activating factor acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol ester esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aflatoxin metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in high-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of high-density lipoprotein particle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of high-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to copper ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to glucocorticoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in reverse cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very-low-density lipoprotein particle remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylcholine-sterol acyltransferase
    Names
    1-alkyl-2-acetylglycerophosphocholine esterase
    Lecithin-cholesterol acyltransferase
    PAF acetylhydrolase
    phospholipid-cholesterol acyltransferase
    platelet-activating factor acetylhydrolase
    NP_058720.2
    XP_006255503.1
    XP_038953400.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017024.3 → NP_058720.2  phosphatidylcholine-sterol acyltransferase precursor

      See identical proteins and their annotated locations for NP_058720.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      O35849, P18424
      UniProtKB/TrEMBL
      A0A8L2QED8, A6IYU6
      Related
      ENSRNOP00000026583.5, ENSRNOT00000026585.7
      Conserved Domains (1) summary
      cl21494
      Location:83 → 408
      Abhydrolase; alpha/beta hydrolases

    RNA

    1. NR_190829.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50744598..50748064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097472.2 → XP_038953400.1  phosphatidylcholine-sterol acyltransferase isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:59 → 384
      Abhydrolase; alpha/beta hydrolases

    2. XM_006255441.3 → XP_006255503.1  phosphatidylcholine-sterol acyltransferase isoform X2

      Related
      ENSRNOP00000100686.1, ENSRNOT00000163120.1
      Conserved Domains (2) summary
      COG0596
      Location:125 → 301
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:44 → 369
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18424.2 GenPept UniProtKB/Swiss-Prot:P18424

    Gene LinkOut

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