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    Il11ra1 interleukin 11 receptor subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il11ra1provided by RGD
    Official Full Name
    interleukin 11 receptor subunit alpha 1provided by RGD
    Primary source
    RGD:621332
    See related
    EnsemblRapid:ENSRNOG00000015068 AllianceGenome:RGD:621332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-11 binding activity and interleukin-11 receptor activity. Involved in embryo implantation. Predicted to be located in extracellular region and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 211.8), Uterus (RPKM 137.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il11ra1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61727650..61737265)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56931824..56941408)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58149150..58159072)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene uncharacterized LOC102547621 Neighboring gene C-C motif chemokine ligand 27 Neighboring gene C-C motif chemokine ligand 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. Kiessling S, et al. J Biol Chem, 2004 Mar 12. PMID 14701802
    2. Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway. Zuo D, et al. J Stroke Cerebrovasc Dis, 2023 Feb. PMID 36521373
    3. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Nieminen P, et al. Am J Hum Genet, 2011 Jul 15. PMID 21741611, Free PMC Article
    4. Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Li R, et al. Reproduction, 2001 Oct. PMID 11570967
    5. Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Bilinski P, et al. Genes Dev, 1998 Jul 15. PMID 9679067, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Ralpha/STAT3 signaling pathway.
      Title: Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway.
    2. IL11RA has a role in apoptosis
      Title: Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables interleukin-11 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-11 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-11 binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables interleukin-11 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-11 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-11 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-11 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein-containing complex binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within decidualization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in developmental process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in head development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-11-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-11-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maternal process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-11 receptor subunit alpha
    Names
    IL-11 receptor subunit alpha
    IL-11R subunit alpha
    IL-11R-alpha
    IL-11RA
    interleukin 11 receptor, alpha chain 1
    interleukin-11 receptor alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434558.1 → NP_001421487.1  interleukin-11 receptor subunit alpha precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q99MF4
      UniProtKB/TrEMBL
      A0A8I6ARG9, A6IIX5

    2. NM_139116.1 → NP_620816.1  interleukin-11 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_620816.1

      Status: PROVISIONAL

      Source sequence(s)
      AF347936
      UniProtKB/Swiss-Prot
      Q99MF4
      UniProtKB/TrEMBL
      A0A8I6ARG9, A6IIX5
      Conserved Domains (3) summary
      smart00409
      Location:33 → 95
      IG; Immunoglobulin
      cd00063
      Location:218 → 310
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:111 → 202
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61727650..61737265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238023.5 → XP_006238085.1  interleukin-11 receptor subunit alpha isoform X1

      Related
      ENSRNOP00000020885.4, ENSRNOT00000020885.7
      Conserved Domains (3) summary
      smart00409
      Location:33 → 95
      IG; Immunoglobulin
      cd00063
      Location:218 → 310
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:111 → 202
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MF4.1 GenPept UniProtKB/Swiss-Prot:Q99MF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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