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    Lactb lactamase, beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lactbprovided by RGD
    Official Full Name
    lactamase, betaprovided by RGD
    Primary source
    RGD:1304788
    See related
    EnsemblRapid:ENSRNOG00000018081 AllianceGenome:RGD:1304788
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 316.9), Liver (RPKM 289.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lactb in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76452679..76469986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67571504..67587592, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72750174..72766307, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554897 Neighboring gene ribosomal protein S27-like Neighboring gene uncharacterized LOC134480198 Neighboring gene U6 spliceosomal RNA Neighboring gene tropomyosin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Keckesova Z, et al. Nature, 2017 Mar 30. PMID 28329758, Free PMC Article
    2. LACTB is a filament-forming protein localized in mitochondria. Polianskyte Z, et al. Proc Natl Acad Sci U S A, 2009 Nov 10. PMID 19858488, Free PMC Article
    3. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine beta-lactamase-like protein LACTB, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106833.1 → NP_001100303.1  serine beta-lactamase-like protein LACTB, mitochondrial

      See identical proteins and their annotated locations for NP_001100303.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474041
      UniProtKB/TrEMBL
      A6KEZ7, D3ZFJ6
      Related
      ENSRNOP00000024452.4, ENSRNOT00000024452.8
      Conserved Domains (1) summary
      pfam00144
      Location:110 → 527
      Beta-lactamase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76452679..76469986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766242.4 → XP_008764464.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZR42
      Related
      ENSRNOP00000080609.1, ENSRNOT00000100085.2
      Conserved Domains (1) summary
      pfam00144
      Location:110 → 245
      Beta-lactamase; Beta-lactamase

    2. XM_063265165.1 → XP_063121235.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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