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    Lrrc18 leucine rich repeat containing 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc18provided by RGD
    Official Full Name
    leucine rich repeat containing 18provided by RGD
    Primary source
    RGD:1311738
    See related
    EnsemblRapid:ENSRNOG00000020080 AllianceGenome:RGD:1311738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311738
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Orthologous to human LRRC18 (leucine rich repeat containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 262.9), Spleen (RPKM 69.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc18 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8259083..8283722)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8253524..8277141)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9234341..9258849)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 170, member B Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene WDFY family member 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC134482457

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013999.2 → NP_001014021.2  leucine-rich repeat-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q66HD6
      Related
      ENSRNOP00000089840.2, ENSRNOT00000096829.2
      Conserved Domains (2) summary
      PLN00113
      Location:55 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      8259083..8283722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600081.3 → XP_017455570.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q66HD6
      UniProtKB/TrEMBL
      A0A8I6AB66
      Conserved Domains (2) summary
      PLN00113
      Location:55 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_063275357.1 → XP_063131427.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q66HD6
      UniProtKB/TrEMBL
      A0A8I6AB66

    3. XM_017600080.3 → XP_017455569.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q66HD6
      UniProtKB/TrEMBL
      A0A8I6AB66
      Related
      ENSRNOP00000104228.1, ENSRNOT00000149065.1
      Conserved Domains (2) summary
      PLN00113
      Location:55 → 200
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    RNA

    1. XR_010058292.1 RNA Sequence

      Related
      ENSRNOT00000027204.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HD6.1 GenPept UniProtKB/Swiss-Prot:Q66HD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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