Vsir V-set immunoregulatory receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vsirprovided by RGD
Official Full Name: V-set immunoregulatory receptorprovided by RGD
Primary source: RGD:1590938
See related: EnsemblRapid:ENSRNOG00000000569 AllianceGenome:RGD:1590938
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human VSIR (V-set immunoregulatory receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 232.4), Lung (RPKM 140.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (28824493..28850175)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (28281582..28307262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29897543..29923381)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD8-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of alpha-beta T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: V-type immunoglobulin domain-containing suppressor of T-cell activation

Names: platelet receptor Gi24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044300.2 → NP_001037765.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor

See identical proteins and their annotated locations for NP_001037765.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8J8XY95

Conserved Domains (3) summary

smart00410
Location:38 → 146

IG_like; Immunoglobulin like

pfam07686
Location:45 → 147

V-set; Immunoglobulin V-set domain

pfam14917
Location:213 → 273

CCDC74_C; Coiled coil protein 74, C terminal
NM_001399050.1 → NP_001385979.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A6K3X6, G3V9P3, Q4KM76

Related

ENSRNOP00000099361.1, ENSRNOT00000165408.1

Conserved Domains (1) summary

cd20980
Location:34 → 179

IgV_VISTA; Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

28824493..28850175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099115.2 → XP_038955043.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1
XM_039099116.2 → XP_038955044.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X2
XM_063279554.1 → XP_063135624.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X3