Mrgprx1 MAS related GPR family member X1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mrgprx1provided by RGD
Full Name: MAS related GPR family member X1provided by RGD
Primary source: RGD:632284
See related: EnsemblRapid:ENSRNOG00000014242 AllianceGenome:RGD:632284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MrgC; Snsr; Mgrg2; Snsr1; Mrgprc; Mrgprx4; Mrgprc11
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: 1q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (106942343..106943314, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (97806099..97807070, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (103378242..103388240, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rat basophilic leukemia-2H3 mast cells express the MrgC11 receptor agonist, RF-amide precursor gene proneuropeptide FF.
Title: Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.
Results suggest that activation of phospholipase C by MrgC agonism may lead to inhibition of high-voltage-activated calcium
Title: The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
The inhibition of morphine tolerance by MrgC receptor was associated with the modulation of astrocytes and microglia in the spinal dorsal horn.
Title: Inhibitory Effects of Mas-Related Gene C Receptor on Chronic Morphine-Induced Spinal Glial Activation in Rats.
MrgC receptors may be a novel target for relieving inflammatory pain.
Title: Activation of Mas Oncogene-Related G Protein-Coupled Receptors Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and Dorsal Root Ganglia Associated with Inflammatory Pain in Rats.
Study suggests that changes in MrgC expression after nerve injury differ temporally in injured and uninjured dorsal root ganglion neurons and that activation of Mrgs may constitute an endogenous mechanism that inhibits the maintenance of neuropathic pain
Title: Temporal changes in MrgC expression after spinal nerve injury.
in lumbar dorsal root ganglia we found cytoplasmic MrgC labeling mainly in small- and medium-sized neurons
Title: Morphological characterization of rat Mas-related G-protein-coupled receptor C and functional analysis of agonists.
analysis of the functional interactions between MRGPR-X1 and TRPV1
Title: Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
We propose that rSNSR1 represents a new member of the receptors expressed on chemosensitive nociceptors responsible for detecting the "inflammatory soup" of mediators generated by tissue damage.
Title: Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: contribution of TRPV1 to SNSR signaling in the pain pathway.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemosensory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemosensory behavior	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member X1

Names: G protein-coupled receptor SNSR; MAS related GPR family member X4; MAS-related G-protein coupled receptor, member C; MAS-related GPR, member C11; MAS-related GPR, member X1; MAS-related GPR, member X4; MAS-related gene C; Mas-related G protein-coupled receptor g2; Sensory neuron-specific receptor; sensory neuron-specific G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.