H2ab3 H2A.B variant histone 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2ab3provided by RGD
Official Full Name: H2A.B variant histone 3provided by RGD
Primary source: RGD:1561666
See related: EnsemblRapid:ENSRNOG00000029736 AllianceGenome:RGD:1561666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H2afb3; RGD1561666
Summary: Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation; mRNA processing; and nucleosome assembly. Predicted to be located in euchromatin. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AB2 (H2A.B variant histone 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: Xq31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (86566994..86567568)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (82362531..82363105)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (88602135..88602485)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in euchromatin	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: H2A.B variant histone 3

Names: H2A histone family, member B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106969.2 → NP_001100439.1 H2A.B variant histone 3

See identical proteins and their annotated locations for NP_001100439.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6IVB5, D4ACM0

Related

ENSRNOP00000045522.2, ENSRNOT00000043727.4

Conserved Domains (1) summary

cl23907
Location:25 → 116

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...