U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mocos molybdenum cofactor sulfurase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361300, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mocosprovided by RGD
    Official Full Name
    molybdenum cofactor sulfuraseprovided by RGD
    Primary source
    RGD:1308496
    See related
    EnsemblRapid:ENSRNOG00000015113 AllianceGenome:RGD:1308496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molybdenum cofactor sulfurtransferase activity. Predicted to be involved in molybdopterin cofactor biosynthetic process. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 48.3), Lung (RPKM 38.3) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mocos in Genome Data Viewer
    Location:
    18p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (16206402..16251928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15931659..15977415)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16590086..16636312)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 6 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene formin homology 2 domain containing 3 Neighboring gene uncharacterized LOC120098112 Neighboring gene heat shock cognate protein 70, pseudogene 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Ichida K, et al. Biochem Biophys Res Commun, 2001 Apr 20. PMID 11302742
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molybdenum cofactor sulfurtransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molybdenum ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in molybdopterin cofactor metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in molybdopterin cofactor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    molybdenum cofactor sulfurase
    NP_001382600.1
    XP_017456477.1
    XP_063133533.1
    XP_063133534.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395671.1 → NP_001382600.1  molybdenum cofactor sulfurase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A1W2Q693, A6J2K9
      Related
      ENSRNOP00000076171.1, ENSRNOT00000093715.3
      Conserved Domains (1) summary
      PLN02724
      Location:28 → 854
      PLN02724; Molybdenum cofactor sulfurase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      16206402..16251928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277464.1 → XP_063133534.1  molybdenum cofactor sulfurase isoform X2

    2. XM_063277463.1 → XP_063133533.1  molybdenum cofactor sulfurase isoform X1

      Related
      ENSRNOP00000100317.1, ENSRNOT00000129170.1

    3. XM_017600988.3 → XP_017456477.1  molybdenum cofactor sulfurase isoform X3

    RNA

    1. XR_001842027.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108425.1: Suppressed sequence

      Description
      NM_001108425.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools