Fbp2 fructose-bisphosphatase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbp2provided by RGD
Official Full Name: fructose-bisphosphatase 2provided by RGD
Primary source: RGD:620930
See related: EnsemblRapid:ENSRNOG00000017637 AllianceGenome:RGD:620930
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FBPase
Summary: Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 425.9), Testes (RPKM 83.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (2241767..2259371)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (2236088..2253702)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (372554..389918, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of FBP2 significantly increased insulin-stimulated glucose uptake in tibialis of chow animals (control 14.3 +/- 1.7; FBP2 17.6 +/- 1.6 micromol/min/100 g) and High fat diet animals (control 9.6 +/- 1.1; FBP2 11.2 +/- 1.1micromol/min/100 g).
Title: Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle.
Insulin and not hyperglycemia plays a crucial role in the nuclear accumulation of FBPase in vivo.
Title: Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver.
Ca2+ appears to be a strong inhibitor of muscle FBPase
Title: Calcium inhibits muscle FBPase and affects its intracellular localization in cardiomyocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128752 (e-PCR)
- UniSTS:212060

Fbp2 (e-PCR), detects polymorphism
- UniSTS:143080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-1,6-bisphosphatase isozyme 2

Names: D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; fructose-1,6-bisphosphatase 2; muscle FBPase

NP_446168.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053716.2 → NP_446168.1 fructose-1,6-bisphosphatase isozyme 2

See identical proteins and their annotated locations for NP_446168.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q9Z1N1

UniProtKB/TrEMBL

A6KQB2

Related

ENSRNOP00000023865.2, ENSRNOT00000023865.5

Conserved Domains (1) summary

cd00354
Location:18 → 330

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...