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    Lpxn leupaxin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lpxnprovided by RGD
    Official Full Name
    leupaxinprovided by RGD
    Primary source
    RGD:1304981
    See related
    EnsemblRapid:ENSRNOG00000012611 AllianceGenome:RGD:1304981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including negative regulation of B cell receptor signaling pathway; substrate adhesion-dependent cell spreading; and transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including focal adhesion; nuclear speck; and podosome. Orthologous to human LPXN (leupaxin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 635.0), Spleen (RPKM 313.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpxn in Genome Data Viewer
    Location:
    1q43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219353319..219387743)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209928297..209963085)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229642437..229674129)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase-like 2 Neighboring gene ciliary neurotrophic factor Neighboring gene zinc finger protein 91 Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 5 subfamily B member 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. Chen PW, et al. Cell Adh Migr, 2010 Oct-Dec. PMID 20543562, Free PMC Article
    2. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. Kaulfuss S, et al. Mol Endocrinol, 2008 Jul. PMID 18451096, Free PMC Article
    3. LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. Tanaka T, et al. Cancer Sci, 2010 Feb. PMID 19917054, Free PMC Article
    4. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. Sundberg-Smith LJ, et al. Circ Res, 2008 Jun 20. PMID 18497331, Free PMC Article
    5. Leupaxin negatively regulates B cell receptor signaling. Chew V, et al. J Biol Chem, 2007 Sep 14. PMID 17640867

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108942

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leupaxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009649.1 → NP_001009649.1  leupaxin

      See identical proteins and their annotated locations for NP_001009649.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088217
      UniProtKB/TrEMBL
      A6I0F1, Q5M852
      Related
      ENSRNOP00000017109.4, ENSRNOT00000017109.8
      Conserved Domains (3) summary
      cd09339
      Location:329 → 380
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
      cl01815
      Location:86 → 172
      DUF1018; Protein of unknown function (DUF1018)
      cl02475
      Location:150 → 204
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      219353319..219387743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108720.2 → XP_038964648.1  leupaxin isoform X4

      Conserved Domains (2) summary
      cd09339
      Location:233 → 284
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
      cl02475
      Location:54 → 108
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_039108719.2 → XP_038964647.1  leupaxin isoform X3

      UniProtKB/TrEMBL
      A0A8I5YCK6
      Conserved Domains (3) summary
      cd09339
      Location:331 → 382
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
      cd09406
      Location:152 → 206
      LIM1_Leupaxin; The first LIM domain of Leupaxin
      cl02475
      Location:213 → 264
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_039108725.2 → XP_038964653.1  leupaxin isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCK6
      Related
      ENSRNOP00000111449.1, ENSRNOT00000152331.1
      Conserved Domains (3) summary
      cd09339
      Location:334 → 385
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
      cd09406
      Location:155 → 209
      LIM1_Leupaxin; The first LIM domain of Leupaxin
      cl02475
      Location:216 → 267
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_063286990.1 → XP_063143060.1  leupaxin isoform X4

    5. XM_039108715.2 → XP_038964643.1  leupaxin isoform X1

      UniProtKB/TrEMBL
      A0A8I5YCK6
      Related
      ENSRNOP00000077943.2, ENSRNOT00000095033.2
      Conserved Domains (3) summary
      cd09339
      Location:341 → 392
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
      cd09406
      Location:162 → 216
      LIM1_Leupaxin; The first LIM domain of Leupaxin
      cl02475
      Location:223 → 274
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version

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