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    Rcsd1 RCSD domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rcsd1provided by RGD
    Official Full Name
    RCSD domain containing 1provided by RGD
    Primary source
    RGD:1304715
    See related
    EnsemblRapid:ENSRNOG00000003283 AllianceGenome:RGD:1304715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304715
    Summary
    Predicted to enable actin filament binding activity; phosphatidylinositol phosphate binding activity; and retromer complex binding activity. Involved in skeletal muscle contraction. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome. Orthologous to human RCSD1 (RCSD domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 345.0), Muscle (RPKM 267.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rcsd1 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80434878..80497312, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77901898..77964309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83854650..83917040, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 14 Neighboring gene transfer RNA proline (anticodon CGG) 3 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene uncharacterized LOC120096304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Eyers CE, et al. Biochem J, 2005 Jul 1. PMID 15850461, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retromer complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle contraction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    capZ-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108349.1 → NP_001101819.1  capZ-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001101819.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6IDH8, F1M4V3
      Related
      ENSRNOP00000106470.1, ENSRNOT00000166515.1
      Conserved Domains (3) summary
      pfam05177
      Location:201 → 299
      RCSD; RCSD region
      pfam05934
      Location:235 → 351
      MCLC; Mid-1-related chloride channel (MCLC)
      pfam15255
      Location:51 → 136
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    2. NM_001415737.1 → NP_001402666.1  capZ-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K7I4, A6IDH9
      Related
      ENSRNOP00000111451.1, ENSRNOT00000132206.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80434878..80497312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769663.4 → XP_008767885.1  capZ-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7I4, A0A8I5ZYN8
      Related
      ENSRNOP00000084185.1, ENSRNOT00000112592.2
      Conserved Domains (3) summary
      pfam05177
      Location:202 → 300
      RCSD; RCSD region
      pfam05934
      Location:236 → 352
      MCLC; Mid-1-related chloride channel (MCLC)
      pfam15255
      Location:52 → 137
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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