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    Rttn rotatin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rttnprovided by RGD
    Official Full Name
    rotatinprovided by RGD
    Primary source
    RGD:1306706
    See related
    EnsemblRapid:ENSRNOG00000038200 AllianceGenome:RGD:1306706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in centriole replication; centriole-centriole cohesion; and ciliary basal body organization. Predicted to act upstream of or within determination of left/right symmetry. Predicted to be located in centrosome. Predicted to be active in centriole and ciliary basal body. Orthologous to human RTTN (rotatin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 87.2), Spleen (RPKM 53.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rttn in Genome Data Viewer
    Location:
    18q13
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84495813..84673079)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82220999..82398334)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (86071884..86247486)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 2 Neighboring gene PCNA clamp associated factor, pseudogene 2 Neighboring gene uncharacterized LOC134483073 Neighboring gene prothymosin alpha like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RTTN mutations link primary cilia function to organization of the human cerebral cortex. Kheradmand Kia S, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939636, Free PMC Article
    2. Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos. Faisst AM, et al. Mech Dev, 2002 Apr. PMID 11900971
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole-centriole cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ciliary basal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rotatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170436.2 → NP_001163907.2  rotatin

      Status: VALIDATED

      Source sequence(s)
      FN802245, JAXUCZ010000018
      Conserved Domains (1) summary
      pfam14726
      Location:16 → 112
      RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      84495813..84673079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096615.2 → XP_038952543.1  rotatin isoform X1

      Related
      ENSRNOP00000068057.3, ENSRNOT00000076159.3
      Conserved Domains (1) summary
      pfam14726
      Location:16 → 112
      RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

    2. XM_039096617.2 → XP_038952545.1  rotatin isoform X3

      UniProtKB/TrEMBL
      D3ZS92
      Related
      ENSRNOP00000112188.1, ENSRNOT00000144544.1
      Conserved Domains (1) summary
      pfam14726
      Location:16 → 112
      RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

    3. XM_039096616.2 → XP_038952544.1  rotatin isoform X2

      Conserved Domains (1) summary
      pfam14726
      Location:16 → 112
      RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

    4. XM_063277155.1 → XP_063133225.1  rotatin isoform X4

      Related
      ENSRNOP00000054965.6, ENSRNOT00000058160.7

    5. XM_039096620.2 → XP_038952548.1  rotatin isoform X6

      UniProtKB/TrEMBL
      A0A096MJA7

    6. XM_039096618.2 → XP_038952546.1  rotatin isoform X5

      Related
      ENSRNOP00000102969.1, ENSRNOT00000167449.1

    7. XM_039096619.2 → XP_038952547.1  rotatin isoform X6

      UniProtKB/TrEMBL
      A0A096MJA7

    8. XM_039096622.2 → XP_038952550.1  rotatin isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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